الفهرس 
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Abstract
T
he serologic panel for IBD is rapidly expanding. So far, antibodies against Saccharomyces cerevisiae (ASCA) and perinuclear antineutrophil cytoplasmic proteins (p-ANCA) have been used in diagnosis of IBD, to distinguish Crohn’s disease (CD) from ulcerative colitis, and to predict the risk of complications of CD (Lewis JD, 2011).
For the inflammatory bowel disease, β2-M was suggested to be used as an activity parameter. B2-M serum levels as an index of T-lymphocytes and macrophages activation in IBD patients reflects the degree of activity and severity of the inflammatory response (Yilmaz B et al., 2014). As an inflammatory marker, B2-M has been investigated in patients with IBD in several studies. However, the results were conflicting and not all authors were able to confirm a correlation (Yilmaz B et al., 2014).
The current work was designed to study the role of beta 2 microglobulin (B2-M) & P-ANCA as a simple, easy and available predictors of diagnosis and disease activity in patients with Ulcerative colitis.
To fulfill such purpose, we studied forty patients with confirmed ulcerative colitis, twenty control subjects with irritable bowel syndrome and twenty healthy control.
We subdivided the ulcerative colitis patients into two groups:
Twenty patients with active UC, they were 10 (50%) males and 10 (50%) females. There ages ranged between 17 and 49 years (mean 35 year-old).
Twenty patients with inactive UC (under treatment), they were 7 (35 %) males and 13 (65 %) females. There ages ranged between 23 and 52 years (mean 35.1year-old).
In the current study we also compared between cases of active UC and inactive UC as regards laboratory parameters (ESR, CRP, Hb level, WBCs and albumin level). There were higher mean CRP values among active cases of UC compared to inactive cases and the difference is of high statistical significance. And although there are also higher mean ESR values among cases with active UC compared to cases with inactive UC but the difference is not statistically significant.
On comparison between the four different groups;(cases with active and inactive UC, IBS and control as regards the mean (B2-M)) we found that; higher mean of (B2-M) levels among active UC group when compared to the other three groups the difference was of high statistical significance. And also, there were higher mean of Beta 2 microglobulin (B2-M) levels among inactive UC when compared to IBS and control groups but the difference is statistically not significant.
Also, we compared between disease extent by endoscopy in UC patients and the mean Beta 2 microglobulin (B2-M). The results showed higher mean Beta 2 microglobulin (B2-M) among cases with extensive UC and pancolitis compared to cases with left sided colitis and proctosigmoiditis and the difference was significant statistically.
Regarding the P-ANCA in the four different study groups; that most of active UC cases (80 %) had positive P-ANCA while only 15 % of the inactive cases had positive P-ANCA and the difference was highly statistically significant. All cases of IBS-control and normal-control had negative PANCA.
Most of positive P-ANCA ulcerative colitis cases (42.1%) had extensive disease involvement, (31.6%) had left sided colitis, (21.1%) had proctosigmoiditis and only (5.3%) have pancolitis.
We also found most of P-ANCA positive ulcerative colitis patients (52.6%) had moderate endoscopic activity and (21.1%) had severe endoscopic activity, while only (10.5%) had mild activity.
Lastly, we found higher mean Beta 2 microglobulin (B2-M) levels in positive PANCA ulcerative colitis patients than in negative PANCA patients and the difference was highly significant.