الفهرس 
LIVER CIRRHOSISOnly 14 pages are availabe for public view
 |  | from | 280 |  |  |
| | | from | 280 | | |
Abstract
Phypertension is an abnormal elevation in the blood
pressure within the portal circulation which is caused by a
functional resistance to blood flow at any part of portal venous
system and also increase in the blood flow of the portal venous
system (De Franchis and Primiganim, 2001).
With this in mind, in our study we used the Spleen
stiffness measurement by TE and SARI. The aim of this work
was to identify parameters which might non-invasively predict
the presence of any OV in patients of chronic liver disease and
in the same time to assess the predictiveness of these identified
rules in patients with cirrhosis.
60 cases with chronic liver diseas were selected. Upper
gastro-intestinal endoscopy was done for all cases for the
presence of OV; accordingly the patients were then divided into
three groups according to the presence/absence of any
esophageal varices and its grading.We evaluated the
biochemical parameters for all patients, including: total and
direct bilirubin, ALT, AST, alkaline phosphatase, serum
albumin, prothrombin time, INR, and CBC including platelet
count.All patients were classified according to Child-Pugh’s
criteria. Also, an ultrasonography of the abdomen was done to
measure the maximal spleen bipolar diameter, PV diameter,
ascites and SARI. We also measured spleen stiffness using
fibroscan for all patients.We found that, spleen stiffness measured by TE and
SARI were significantly different among patients with
esophageal varices when compared to those without esophageal
varices.
The best cut off point for SS for prediction of esophageal
varices in patients with chronic liver disease was 70.80Kpa
with sensitivity of 80% and specificity of 70% according to our
results.
The best cut off point for SARI for prediction of
esophageal varices in patients with chronic liver disease was
0.66 with sensitivity of 85% and specificity of 77.5% according
to our results.