الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
The relationship between kidney and thyroid hormones may be bi-directional, as Kidney has an important role in metabolism and elimination of thyroid hormones, where thyroid hormones are involved in renal development and growth, as well as sodium and water homeostasis and the influence of GFR. However, the association between CKD and thyroid dysfunction is not well defined yet, although it has been corroborated in different epidemiologic studies.
The aim of this work is to study thyroid dysfunction in CKD pediatric patients in different CKD stages.
We conducted a pilot cross sectional study on 60 pediatric patients with different stages of CKD, attending nephrology conservative clinic, Children Hospital, Ain Shams University. Patients were classified according to CKD stages (22 patients in CKD stage 2, 18 patients in CKD stage 3, 12 patients in CKD stage 4 and 8 patients in CKD stage 5). A full history was taken from patients or their care-givers, including sociodemographic status (age and sex), cause of CKD and duration of sickness. Laboratory data were collected including: serum TSH, serum FT4, serum FT3, and serum FrT3.
Data of 60 pediatric patients were collected, their mean age 6.6±3.7 years. Males versus females 58.3% vs 41.7%.
Most participants (64%) had abnormal thyroid function test results, 30% of them had hypothyroidism (10% had primary overt hypothyroidism and 20% had primary subclinical hypothyroidism), percentage was increasing from CKD stage 2 to 3, then declined from CKD stage 3 to 5.
Other thyroid dysfunctions were observed in this study, including subclinical hyperthyroidism and secondary hypothyroidism.
Conclusion:
In conclusion, this study demonstrated that there is prevalence of thyroid dysfunction in CKD patients, but with no statistical significance with decline in eGFR. Results suggest that there is decline in percentage of hypothyroidism and non-thyroidal illness with progression of CKD stages.