الفهرس 
TuberculosisOnly 14 pages are availabe for public view
 |  | from | 172 |  |  |
| | | from | 172 | | |
Abstract
Tuberculosis is one of the important public health
problems across the world especially in developing
countries. The gold standard in diagnosis of tuberculosis is
sputum culture which take a lot of time and delay the
diagnosis. So, there has been a great demand for finding
new methods to diagnose TB quickly and accurately.
Recent studies reported that measuring of serum
adenosine deaminase (ADA) level and serum cancer
antigen 125 (CA125) is a biomedical method help in
diagnosis of pulmonary tuberculosis.
The aim of this study is correlate between serum
ADA and serum CA125 in assessment of severity in
pulmonary tuberculosis.
This study included 45 patients admitted in Abbassia
Chest Hospital during the period from January 2016 to
April 2017.
The patients were classified into three groups:
group I: 15 patients with active pulmonary tuberculosis
diagnosed with sputum positive and suspected chest
radiography.group II: 15 patients with multidrug resistant pulmonary
tuberculosis diagnosed by sputum culture and drug
sensitivity test and receiving antituberculous treatment for
more than 6 months.
group III: 15 Patients with sputum negative pulmonary
tuberculosis who received treatment for 2 months.
All included patients were subjected to detailed,
medical history, full clinical examination, chest
radiography and laboratory investigations.
In this study, the age of patients was ranged (20-50
ys), 71.11% of patients were males and 28.89% were
females, about 77% of them were sputum positive and 33%
were sputum negative. One third of cases had drug resistant
tuberculosis, 86% of them were rifampicin resistant, 6%
were INH resistant, and 6% were resistant to rifampicin,
INH and streptomycin. In the studied cases, moderate
advanced lesion (46%) was the most frequent followed by
minimal lesion (40%) and far advanced one (13%).
In the current study, there was insignificant statistical
difference in serum CA125 and ADA regarding age and
sex, but there were statistically significant difference
among the studied groups as regard sputum ZN, chest x-ray
and ESR.There was statistically significant difference among
three groups in serum CA125, and serum ADA. They were
statistically significant higher in group I and lower in group
III after receiving antituberculous treatment and sputum
conversion, but there was no difference in both markers
between group II and III.
Serum level of CA125 and ADA were statistically
significant higher in far advanced and moderate advanced
disease than minimal one,
As regard sputum ZN, there was no statistical
difference in serum CA125 between sputum positive and
negative cases, but serum ADA was significantly higher in
positive cases than negative one.
Also, there was statistically significant positive
correlation between serum ADA, serum CA 125 and ESR.
Finally, there was no statistical significant correlation
between the two markers.