الفهرس 
Literature Survey On The Metal Complexes Containing The chromone Moiety.Only 14 pages are availabe for public view
Abstract
SUMMARY
Summary
Chromones are the most widespread class of naturally occurring compounds. chromones have potential beneficial effects for human health. Among the diverse biological properties that these compounds possess are included activities like anti-inflammatory, antibacterial, antitumor, antioxidant, anti-HIV, antiviral and antiallergenic activities. 3-Formylchromone and its substituents have attracted a considerable interest as highly reactive compounds, which can form the metal-heterocyclic complexes with useful properties due to the availability of oxygen as a donor center.
In the current work, the chelating behavior of 3-formylchromone towards Cu(II), Ni(II), Co(II), Zn(II) and Cd(II) ions was investigated. Thus, a series of binary and ternary metal complexes have been synthesized by using metal ions with different anions (AcO–, NO3–, SO42–, ClO4–, Cl– and Br–) and secondary ligands including N,O-donor; 8-hydroxyquinoline or N,N-donor; 1,10-phenanthroline and 2,2’-bipyridyl. The prepared complexes have been characterized by micro analytical, spectral (IR, electronic, ESR and mass spectra), thermal, magnetic and conductivity techniques.
The analytical and spectroscopic techniques revealed that the ligand behaves as a neutral bidentate, forming chelates that reflect the non-coordinating or weakly coordinating power of the ClO4– and NO3– anions as compared to the strongly coordinating power of AcO– and SO42– anions. The obtained complexes were formed with different molar ratios according to the anion. In case of AcO–, ClO4– and Cl–(with Ni(II) and Co(II) ions) anions, 1:2; M:L complexes were obtained. However, in case of NO3– anion, 1:3; M:L complexes were obtained. In case of SO42–, Cl– and Br– (with Cu(II) ion) anions, 1:1;
SUMMARY
M:L complexes were obtained. All ternary complexes showed 1: 2: 1, 1:1:1 and 1:1:2 stoichiometry (metal : ligand : secondary ligand).
The results showed that all binary metal complexes exhibited octahedral geometry except the copper(II) complex 6, which exhibited square planar geometrical arrangement. Also, all the ternary metal complexes revealed an octahedral geometry.
Thermal gravimetric analysis (TGA) was performed for some complexes of the chromone ligand. Thermodynamic parameters (ΔG, ΔH, ΔS and Ea) of the metal complexes were calculated using Coats-Redfern method and standard thermodynamic equations, and this was performed using the thermal degradation of the solid complexes using TGA curves.
Molecular orbital calculations were carried out and the results were correlated with the experimental data.
The ligand and its metal complexes were screened for their antimicrobial activity against Staphylococcus aureus and Bacillus subtilis as Gram-positive bacteria, Escherichia coli and Salmonella typhimurium as Gram-negative bacteria, Candida albicans and Aspergillus fumigatus as fungal strains. The ligand exhibits intermediate to higher bioactivity against all organisms and its activity is promising toward Candida albicans. Most of the complexes are biologically active and complexes 8 and 28 displayed promising antimicrobial activity towards all organisms.