الفهرس 
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Abstract
P
TB continues to be the leading cause of perinatal morbidity & mortality throughout the world. Despite advances in perinatal care, the incidence of PTL has not decreased significantly over the past 40 years. The use of biological markers to enhance the clinical accuracy in predicting PTB has been recently proposed.
In this study IL6 gene promotor polymorphism used as a predictive markers for PTL.
In this study, a total of 160 pregnant women were included.
Patients were divided into 2 groups:
group A: Included Study group (n = 80)
Evidence of characteristic established preterm labor; Regular uterine contractions, cervical dilatation more than 4 cm, cervical effacement more than 50%.
group B: Included control group (n = 80) Normal pregnancy without any complications.
Gestational age were assessed on the basis of the last normal menstrual period and confirmed by sonographic measurements in the first trimesters.
All women were subjected to full history taking, full general, abdominal and pelvic examination, in addition to special investigation which were IL6 gene assay. The patients were followed up till the time of delivery & gestational age at delivery is determined.
It was found that IL6 gene promotor polymorphism (174 G/G) significantly higher in study group compared to control group. This was of high statistical significance.
It was found that IL6 gene promoter polymorphism (174 G/G) significantly related to bad neonatal outcome.