الفهرس 
Introduction and aim of the workOnly 14 pages are availabe for public view
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Abstract
Summary
H. pylori is a microaerophilic, small, spiral, highly motile, Gram negative bacillus that colonizes the mucous layer of the stomach and the oral cavity. It has been recognized as the main cause of peptic ulcer and in 1994, H. pylori has been classified as class Ι carcinogen for the development of gastric cancer. However most infected people (>70%) are asymptomatic and the infection once acquired is believed to last the whole entire life.
The aim of the current study was to diagnose H. pylori infection by different modalities in gastric biopsy and saliva with dental plaque samples. Also to detect H. pylori antigen in stool and do susceptibility pattern to some selected antibiotics.
Thirty patients were included in this study. Two gastric biopsies and saliva with dental plaque samples were taken from each patient. RUT, culture on selective media and biochemical reaction were performed. Thereafter, antibiotic sensitivity was done using six antibiotics. Culture for saliva with dental plaque sample on Dent supplemented blood agar had sensitivity 96.3% while RUT showed 78.9% sensitivity and The One Step H. pylori Antigen Test Device (Feces) showed sensitivity 90%, in comparison of the culture results of gastric biopsy sample on Dent supplemented blood agar as agold standard.
H. pylori isolates were almost completely resistant to metronidazole, however, sensitivity to amoxicillin was very evident, followed by amoxicillin clavulinic, clarithromycin, then, ampicillin salbactam and tetracycillin.
H. pylori infection is a common and dangerous health problem. Therefore, the development of specific tests to diagnose H. pylori is recommended. Also effective eradication is essential to prevent the development of gastric cancer.