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العنوان
The Association Between ANA, Anti
Ds DNA and Polycystic Ovary
Syndrome /
المؤلف
Abou-El-Magd,Nermin Ahmed Mahmoud.
هيئة الاعداد
باحث / Nermin Ahmed Mahmoud Abou-El-Magd
مشرف / Sherif Mohamed Abd-El-Hamid
مشرف / Mohamed Osama Taha
مشرف / Mohamed Tarif Hamza
تاريخ النشر
2017
عدد الصفحات
143p.;
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
أمراض النساء والتوليد
تاريخ الإجازة
1/1/2017
مكان الإجازة
جامعة عين شمس - كلية الطب - امراض النساء و التوليد
الفهرس
Only 14 pages are availabe for public view

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from 143

Abstract

PCOS is the most common endocrinopathy in adult women,
and is emerging as common cause of menstrual
disturbances in adolescent population.
Prevelance of PCOS could differ among different
population. However prevelance of PCOS seems to increase
rapidly owing to the world- wide epidemic of obesity related to
unhealthy dietary habits and physical inactivity.
The aetiology of PCOS remains uncertain but there is
increasing evidence for auto immune disease so screening for
auto antibodies in PCOS women may help in diagnosis of
PCOS.
It has been postulated that all women with PCOS may
have insulin resistance. Insulin resistance has been
demonstrated to be greater in both lean and obese women with
PCOS compared with non-PCOS women of comparable
weight, suggesting that the defect is intrinsic to this disorder.
To establish the diagnosis of PCOS, the goal is to
confirm ovarian hyperandrogenism, and exclude other causes
of hyperandrogenism and menstrual dysfunction such as
adrenal or ovarian tumours, non classical adrenal hyperplasia,
cushing’s syndrome, hyperprolactinemia, and thyroid disease.
The recent PCOS consensus meeting held in Rotterdam
determined the diagnostic criteria for PCOS as (i) oligo-and /or
anovulation, (ii) clinical and /or biochemical signs of hyperandrogensim and (iii) polycystic ovary morphology on
ultrasound scan, defined as the presence of >12 folicles in each
ovary (with one ovary being sufficient for diagnosis) measuring
2 to 9mm in diameter and /or increased overian volume >10 ml
after exclusion of other causes of androgen excess. Two out of
the three are required for the diagnosis of PCOS.
In virgin polycystic ovary syndrome (PCOS) patients,
transabdomenal sonography is the preferential method of pelvic
examination. Magnetic resonance can provide vastly greater
delineation of the structural components of the ovary in obese
women with PCOS and thus can serve as an excellent
investigational technique.
Life-style modification is very important in the treatment
of PCOS women, as weight loss and exercise show a striking
improvement in ovulatory function and features of
hyperandrogenism. Oral contraceptives may play a role in
therapy for women with PCOS.
Oral contraceptives decrease ovarian androgen
production and increase SHBG, resulting in lower levels of
biologically active androgens and stabilized hair growth.
Anti-androgens (spironolactone, finasteride, flutamide)
are useful in stopping hair growth in women whose condition is
not responsive to oral contraceptives.
For the severely hirsute patients with PCOS resistant to
oral contraceptives and anti-androgens, GnRH agonists (e.g,leuprolide acetate 3.75 mg intramuscularly each month for 6
months).
For patients with recurrent pregnancy loss, pituitary
suppression with GnRH agonists or luteal support
(progesterone, human chorionic gonadotropin) have been
reported to be helpful.
Gonadotropin therapy may also be effective and remains
the most frequently used therapy in clomiphene-resistant cases.
Surgical ovulation induction (laparoscopic ovarian
drilling, wedge resection) has been shown to be effective.
Insulin-sensitizing agents have been proposed as the
treatment for this disorder. where as most current regimens
treat the symptoms of PCOS, insulin-sensitizing agents are
intended to correct the underlying metabolic defect of this
syndrome.
The aim of our study was to determine the association of
autoimmunologic processes in women with PCOS.
Thirty patients with PCOS were selected from Ain
Shams University Hospital clinic compared with thirty agedmatched
health fertile control as regard autoimmune markers
(ANA, Anti-dsDNA).
The results of our study show significant increase in
autoimmune markers (Anti-dsDNA) in PCOS patients
compared with healthy control. These results suggest that a role
for auto immunologic processes might be present in the
pathogenesis of PCOS.