الفهرس 
The Fetal Membranes and the Amniotic FluidOnly 14 pages are availabe for public view
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Abstract
Preterm PROM complicates 2% to 20% of all deliveries. The accurate diagnosis of Preterm PROM is important, because it is associated with infectious morbidity of mother and fetus, cord prolapse, and preterm labor. The absence of a non-invasive gold standard method for the diagnosis of PROM has led to the search for the alternative biochemical markers which have high amniotic concentration.
The aim of our study was to evaluate the reliability of vaginal fluid human chorionic gonadotropin for diagnosis of premature rupture of membranes.This prospective case control study was conducted at Ain Shams Maternity Hospital during the period from Mars 2015 to May 2016. The study included 60 pregnant women between 24-36 weeks of gestation divided into two groups. group I consisted of 30 patients with positive history of vaginal leakage and positive fluid leakage observed using sterile Cusco speculum. group II consisted of 30 pregnant women without any complaint or complication. All patients underwent full history, general examination, abdominal examination and sterile Cusco speculum examination. The vagina was washed by injection with a syringe filled with 5ml of saline solution, and 3ml the washing fluid was collected from the posterior vaginal fornix. The collected fluid was sent immediately to the laboratory for measuring of vaginal fluid quantitative β-hCG.
Analysis of results using Receiver-operator characteristic curve showed that Vaginal β-hCG had excellent diagnostic value as denoted by an area under the ROC curve of 1.0 with 95% confidence limits ranging from 0.94 to 1.0 (p-value <.0001). The best cut-off value was a vaginal β-hCG concentration of >56 mIU/ml which had a sensitivity of 100% with 95% confidence limits ranging from 86.2% to 100% and a specificity of 100% with 95% confidence limits ranging from 86.2% to 100%.
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