الفهرس 
REVIEWOnly 14 pages are availabe for public view
 |  | from | 125 |  |  |
| | | from | 125 | | |
Abstract
The aim of this work is to study the prevalent iron parameters (serum iron, total iron binding capacity, transferrin saturation and serum ferritin) among hemodialysis patients in insurance hemodialysis centers.
This study was conducted on 200 patients, who have end stage renal disease, on regular hemodialysis in dialysis centers of insurance hospitals.
All the patients were HBVsAg negative and HIV Ab negative. from them: 108 patients were HCV Ab positive while 92 patients were HCV Ab negative.
All the patients were subjected to full clinical examination and detailed history taking including the following: (Age, sex, duration of hemodialysis, the dialysis time per week, history of GIT bleeding, history of H2blocker or proton pump inhibitor intake, history of erythropoietin intake & its dose per week, history of I.V. iron intake & its dose per week and history of blood transfusion).
The following laboratory investigations were done for each patient: 1- Iron parameters (serum iron, total iron binding capacity and serum ferritin). 2- Complete blood picture. 3- Urea and creatinine. 4- C-reactive protein (CRP) and serum albumin.
The prevalent levels of iron parameters among these patients were as the following: the mean serum iron level is 63.95 µg/dl, the mean transferrin saturation (TSAT) percentage is 30.08% and the mean serum ferritin level is 715.0 ng/ml.
We founded that the prevalence of iron deficiency was 42.5% while the prevalence of iron overload was 34% of the patients. There was no statistically significant difference as regard neither the duration of hemodialysis nor the dialysis time per week between patients with iron deficiency and those with iron overload.
There was no statistically significant difference as regard neither iron deficiency nor iron overload prevalence between each of: male and female patients, CRP +ve and CRP –ve patients, patients who receive erythropoietin and those who do not, patients who received blood transfusion and those who didn’t, HCV +ve and HCV -ve patients and patients who had history of GIT bleeding and those who did not.
There was a statistically significant difference between patients who receive IV iron therapy and those who do not as regard each of: iron deficiency prevalence (being higher in those who do not receive IV iron therapy) and iron overload prevalence (being higher in those who receive IV iron therapy).
There was a statistically significant difference between patients who receive H2 blockers or proton pump inhibitors and those who do not as regard each of: iron deficiency prevalence (being higher in those who do not receive H2 blockers or proton pump inhibitors) and iron overload prevalence (being higher in those who receive H2 blockers or proton pump inhibitors).
There was a statistically significant positive correlation between transferrin saturation and serum ferritin. Also, there was a statistically significant positive correlation between hemoglobin with each of the following parameters: serum iron, transferrin saturation (TSAT) and serum ferritin.
There was a statistically significant positive correlation between MCV with each of the following parameters: serum iron, transferrin saturation (TSAT) and serum ferritin. Also, there was a statistically significant positive correlation between MCH with the same iron parameters.
There was a statistically significant difference between CRP +ve and CRP -ve patients as regard each of: serum iron and ferritin level (being higher in CRP +ve patients) and transferrin saturation (being higher in CRP -ve patients). While, there was no statistically significant difference as regard hemoglobin level between the two patient groups.
There was no statistically significant correlation between erythropoietin dose and hemoglobin level while there was a statistically significant positive correlation between erythropoietin dose with each of transferrin saturation and serum ferritin.
There was a significant positive correlation between I.V. iron dose with each of serum iron, transferrin saturation and serum ferritin while there was no correlation between I.V. iron dose and hemoglobin level.
There was no statistically significant difference regarding neither serum iron, transferrin saturation, serum ferritin nor hemoglobin between HCV +ve and HCV -ve patients.