الفهرس 
Introductionيوجد فقط 14 صفحة متاحة للعرض العام
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المستخلص
The invasive fine needle aspiration (FNA) biopsy remains the base investigative tool for thyroid malignancy despite its limitations. This study aimed to evaluate whether serum galectin-3 (Gal-3) or tissue inhibitor of metalloproteinase-1 (TIMP-1) could be used as serum biomarkers for improving thyroid cancer diagnosis. Using ELISA, Gal-3 and TIMP-1 were identified in the sera of 90 Egyptian patients comprised of 39 thyroid cancers, and 51 benign thyroid tumors. Further, multiple regression analyses and ROC curve analyses were applied to create a diagnostic score for thyroid cancer diagnosis. TIMP-1 was reduced significantly in thyroid cancer than in benign tumors (P < 0.001), but Gal-3 was slightly increased in thyroid cancer patients (p=0.391). TIMP-1 produced 0.848 of area under curve (AUC), plus 83% sensitivity and 75% specificity, while Gal-3 yielded 0.664 AUC with 72% sensitivity and 55% specificity for identifying thyroid cancer. The score combining TIMP-1, Gal-3, FNA, and ultrasound (US) was then constructed yielding 0.898 AUC for thyroid cancer detection with 89% sensitivity and 82% specificity. For the first time, combining serum markers of TIMP-1 and Gal-3 with regular methods of FNA and US, provides superior accuracy for thyroid cancer diagnosis and proper management.