الفهرس 
General Principles of Blood Transfusion
Non-haemolytic febrile reactionsOnly 14 pages are availabe for public view
 |  | from | 74 |  |  |
| | | from | 74 | | |
Abstract
Othe past decade, there has been an increase in the use of
hematopoietic stem cell transplants (HSCT) to treat
hematologic malignancies, life-threatening nonmalignant
hematologic disorders and a continuously expanding list of
diseases.
Even after using newer, less intensive regimens, patients
undergoing HSCT still receive frequent blood products as part
of their supportive therapy which had impacted transfusion
service all over the world.
In light of substantial cost and some risk associated with
blood product use and the fact that the role of blood transfusion
in clinical outcomes in patients undergoing HSCT still poorly
understood we pursued a detailed study to gain more insight and
knowledge about blood component transfusion practices in
populations undergoing HSCT.
Hence, the aim of this study was to investigate the
relationship between blood transfusion and the following sequels
that has been recognized to hematopoietic stem cell
transplantation such as the incidence of infection‚ acute and
chronic GVHD and overall survival Using retrospectively collected data from the Ain shams
Bone Marrow Transplant unit records, we reviewed
demographics and complications in 50adult patients who
underwent HSCT. This was supplemented with complete and
detailed transfusion data for 3 months before to 1 year after
HSCT.
The survival time of these patients was tracked over a
period of 3 years.
The patients were divided into 2 groups:-
30 patients who received less than 10 units (group 1) and
20 patients who received more than 10 units (group 2). To
evaluate the relation between the amount of blood consumed and
the outcome of HSCT.
After analyzing the collected data we found that there was
a positive relationship between amount of blood transfusions and
the rate of infection but no impact on the time of infection was
observed.
There was a positive relationship between the amount of
blood transfusions and incidence of GVHD but no impact on the
affected organs nor the type of GVHD was observed.
Finally, there was a positive relationship between the
amount of blood transfusion and the decreased median time for
survival which was estimated in this study as 2 years.