الفهرس 
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Abstract
Wound healing is a complex dynamic series of events which starts within seconds after the injury with haemostasis, followed by three distinct overlapping phases called inflammation, cell proliferation and remodeling
Platelet rich fibrin (PRF) is the latest development of the platelet concentrates developed by Choukroun et al(7, 8) in France and many studies published its effect in improving the healing of both hard and soft tissue injuries.
Honey contains a variety of dietary nutrients that are useful for good health. It was mentioned in the holy Quran and it was also described as therapy in many Ancient civilizations. Honey also has antimicrobial, anti-inflammatory and antioxidant effects which are great criteria to use for wound healing.
This study was conducted to evaluate and compare the effect of PRF and honey on wound healing in albino rabbits.
Twenty-one New Zealand albino rabbits, 1500 to 2000 grams were used in the experiment.
Three parallel full-thickness skin incisions measuring 3 cm in length(22)with 2 cm space between each, were performed under aseptic conditions on the backs of 21 rabbits.The first wound was on the right side of the rabbit and was left untreated (control group G1). PRF was applied to the middle wound (G2). One ml of pure unheated honey was applied to the wound on the left side (G3)(143). Then all wounds were sutured with 3–0 suturing material.
At each time interval of 3,7 and 14 days postoperatively, seven rabbits were sacrificed by overdose of anesthesia (Ketamine) and tissue biopsies were collected from each wound to be examined.
The study groups (G1, G2 and G3) were then divided into subgroups according to the study durations 3, 7 and 14 days. Three days was coded as subgroup A, 7 as subgroup B and 14 days as subgroup C.
The specimens were fixed immediately in 10% buffered formalin solution, decalcified and embedded in paraffin wax blocks. Sections were obtained and stained with H and E for histomorphometric analysis comprising inflammatory cell and newly formed blood vessels counts in addition to the epithelial thickness measurements (ET).
In our results the untreated wounds showedamoderate inflammatory cell count early in the healing process then it decreased to a mild one at 14 days postoperatively. They also demonstrated a small number of newly formed blood vessels. Most of the control wounds started to show a repithelialization at 7 days postoperatively while all cases healed at 14 days postoperatively.
For the PRF treated wounds, a moderate inflammatory cell count was notedat 3 days postoperatively. This inflammatory cell count decreasedintoa mild one at 14 days postoperatively. PRF treated wounds also showed a large number of newly formed blood vessels during the whole healing process. Some of these wounds started to show a repithelialization at 7 days postoperatively while all cases healed at 14 days postoperatively.
The honey treated woundsshowedamoderateinflammatory cells count at the early phases. This inflammatory cells count decreasedto mild one at 14 days postoperatively. Honey treated wound showed a moderate neoangiogenesis during the whole healing process with a slight decrease at 14 days postoperatively. Some of these wounds started to showrepithelialization at 7 days postoperatively while all cases healed at 14 days postoperatively.
Based upon these data it could be concluded that the PRF and honey treated wounds did not show any acceleration in the healing process or superiority when compared to the untreated wounds.