الفهرس 
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Abstract
Background: Late onset sepsis and necrotizing enterocolitis are major cause of mortality and morbidity in preterm neonates mainly due to immaturity of their innate and adaptive immune system. Bovine Colostrum is the first milk that mammals produce after parturition, it contains antimicrobials such as lactoferrin and lactoperoxidases, immunological and growth factors.
Objective: To assess effect of oral bovine colostrum in prevention of late onset sepsis and necrotizing enterocolitis when used as gut priming in premature neonates as long as neonate can tolerate oral intake.
Methods: Our study was conducted on 51 premature neonates below 34 weeks gestational age, Mean gestational age 31.98 ± 2.04 weeks, admitted at Ain shams university NICUs. The enrolled patients were subdivided into three groups; group A (Reference group) are infants with exclusive maternal breast milk initially then predominant (maternal breast milk more than 75% of the total), group B (intervention group) are infants with exclusive bovine colostrum then added with infant formula, and group C (control group) are infants with artificial formula initially then predominantly artificial feeding (maternal breast milk less than 25% of the total).
Results: Bovine colostrum high amounts of the insulin-like growth factors (IGFs), weight increment in this study was nearly equal in both breast milk and intervention bovine colostrum group. Mean of weight increment was 93.53 ±43.60 and 92.06 ± 32.84 respectively, Which was greater than weight increment in artificial formula group with mean 64.12 ± 21.45.
Conclusion: In the present study, we found a negative correlation between initial and follow-up level of CD4 and CD 4 +25 high affinity (activated T regulatory cells) percentage of lymphocytes and change between them and clinical severity and duration of sepsis in studied neonates.
Background: Late onset sepsis and necrotizing enterocolitis are major cause of mortality and morbidity in preterm neonates mainly due to immaturity of their innate and adaptive immune system. Bovine Colostrum is the first milk that mammals produce after parturition, it contains antimicrobials such as lactoferrin and lactoperoxidases, immunological and growth factors.
Objective: To assess effect of oral bovine colostrum in prevention of late onset sepsis and necrotizing enterocolitis when used as gut priming in premature neonates as long as neonate can tolerate oral intake.
Methods: Our study was conducted on 51 premature neonates below 34 weeks gestational age, Mean gestational age 31.98 ± 2.04 weeks, admitted at Ain shams university NICUs. The enrolled patients were subdivided into three groups; group A (Reference group) are infants with exclusive maternal breast milk initially then predominant (maternal breast milk more than 75% of the total), group B (intervention group) are infants with exclusive bovine colostrum then added with infant formula, and group C (control group) are infants with artificial formula initially then predominantly artificial feeding (maternal breast milk less than 25% of the total).
Results: Bovine colostrum high amounts of the insulin-like growth factors (IGFs), weight increment in this study was nearly equal in both breast milk and intervention bovine colostrum group. Mean of weight increment was 93.53 ±43.60 and 92.06 ± 32.84 respectively, Which was greater than weight increment in artificial formula group with mean 64.12 ± 21.45.
Conclusion: In the present study, we found a negative correlation between initial and follow-up level of CD4 and CD 4 +25 high affinity (activated T regulatory cells) percentage of lymphocytes and change between them and clinical severity and duration of sepsis in studied neonates.
Background: Late onset sepsis and necrotizing enterocolitis are major cause of mortality and morbidity in preterm neonates mainly due to immaturity of their innate and adaptive immune system. Bovine Colostrum is the first milk that mammals produce after parturition, it contains antimicrobials such as lactoferrin and lactoperoxidases, immunological and growth factors.
Objective: To assess effect of oral bovine colostrum in prevention of late onset sepsis and necrotizing enterocolitis when used as gut priming in premature neonates as long as neonate can tolerate oral intake.
Methods: Our study was conducted on 51 premature neonates below 34 weeks gestational age, Mean gestational age 31.98 ± 2.04 weeks, admitted at Ain shams university NICUs. The enrolled patients were subdivided into three groups; group A (Reference group) are infants with exclusive maternal breast milk initially then predominant (maternal breast milk more than 75% of the total), group B (intervention group) are infants with exclusive bovine colostrum then added with infant formula, and group C (control group) are infants with artificial formula initially then predominantly artificial feeding (maternal breast milk less than 25% of the total).
Results: Bovine colostrum high amounts of the insulin-like growth factors (IGFs), weight increment in this study was nearly equal in both breast milk and intervention bovine colostrum group. Mean of weight increment was 93.53 ±43.60 and 92.06 ± 32.84 respectively, Which was greater than weight increment in artificial formula group with mean 64.12 ± 21.45.
Conclusion: In the present study, we found a negative correlation between initial and follow-up level of CD4 and CD 4 +25 high affinity (activated T regulatory cells) percentage of lymphocytes and change between them and clinical severity and duration of sepsis in studied neonates.
Background: Late onset sepsis and necrotizing enterocolitis are major cause of mortality and morbidity in preterm neonates mainly due to immaturity of their innate and adaptive immune system. Bovine Colostrum is the first milk that mammals produce after parturition, it contains antimicrobials such as lactoferrin and lactoperoxidases, immunological and growth factors.
Objective: To assess effect of oral bovine colostrum in prevention of late onset sepsis and necrotizing enterocolitis when used as gut priming in premature neonates as long as neonate can tolerate oral intake.
Methods: Our study was conducted on 51 premature neonates below 34 weeks gestational age, Mean gestational age 31.98 ± 2.04 weeks, admitted at Ain shams university NICUs. The enrolled patients were subdivided into three groups; group A (Reference group) are infants with exclusive maternal breast milk initially then predominant (maternal breast milk more than 75% of the total), group B (intervention group) are infants with exclusive bovine colostrum then added with infant formula, and group C (control group) are infants with artificial formula initially then predominantly artificial feeding (maternal breast milk less than 25% of the total).
Results: Bovine colostrum high amounts of the insulin-like growth factors (IGFs), weight increment in this study was nearly equal in both breast milk and intervention bovine colostrum group. Mean of weight increment was 93.53 ±43.60 and 92.06 ± 32.84 respectively, Which was greater than weight increment in artificial formula group with mean 64.12 ± 21.45.
Conclusion: In the present study, we found a negative correlation between initial and follow-up level of CD4 and CD 4 +25 high affinity (activated T regulatory cells) percentage of lymphocytes and change between them and clinical severity and duration of sepsis in studied neonates.