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العنوان
PREVALENCE OF PSYCHIATRIC DISORDERS IN A SAMPLE OF PATIENTS WITH chrONIC HEPATITIS C ON INTERFERON, RIBAVIRIN AND SOVALDI THERAPY \
المؤلف
Hemida, Hadeer Khairy Ali.
هيئة الاعداد
باحث / هدير خيري علي حميدة
مشرف / طارق أحمد عكاشه
مشرف / غادة رفعت أمين
مشرف / داليا عبدالمنعم محمود
تاريخ النشر
2017.
عدد الصفحات
278 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
الطب النفسي والصحة العقلية
تاريخ الإجازة
1/1/2017
مكان الإجازة
جامعة عين شمس - كلية الطب - قسم المخ والأعصاب والطب النفسي
الفهرس
Only 14 pages are availabe for public view

from 278

from 278

Abstract

Introduction: The World Health Organization considers chronic hepatitis C (CHC) as a major public health problem and estimates that 3% of the world’s population (170 million people) is infected with hepatitis C virus (HCV) and is at risk of developing liver cirrhosis and liver cancer. The prevalence of hepatitis C virus (HCV) infection varies throughout the world with the highest number in Egypt, ranging from 6% to more than 40% with an average of 13.8%. In populations of blood transfusion recipients over the age of 30, HCV has been reported as high as 73% and in the general population aged 40–60 years it was estimated as high as 55%
Aims: a) To compare the rate of incidence of psychiatric disorders co morbid with chronic hepatitis C in patients groups of: a) those using combination of IFN, Ribavirin and Sovaldi, b) those using combination of Daklinza, Ribavirin and Sovaldi. b) To identify the risk factors that make the patients more vulnerable to have such psychiatric co morbidities.
Methodology: This study aimed at studying the prevalence of psychiatric disorders in a sample of 260 patients’ males and females, aged (18-75), diagnosed with Hepatitis C by PCR and collected from the outpatient clinic of internal medicine and Interferon unit in Damanhur Medical National Institute.Then patients classified into two groups; the first group (G1) included patients receiving peg IFN-α, Ribavirin and Sovaldi, the second group (G2) included patients receiving Daklinza, Ribavirin and Sovaldi.
Results: Socio-demographic characteristics of the sample: The study sample was randomly selected from patients of the outpatient clinic of internal medicine and Interferon unit in Damanhur Medical National Institute. Males constituted 53.1% of the total sample size. The cause of having more men in the sample is probably due to the medical examination which is a perquisite for any locally or onboard job (any institution requires a negative HCV PCR examination). As a result more men are accidentally diagnosed with HCV.
Limitations: Relatively small sample size may not fully reflect factors among all hepatitis c patients in the population and some factors may be hidden. A larger sample selected by stratified randomization including all age groups, different socioeconomic profiles and occupations, and different marital conditions is recommended.
Recommendations: Application of the study or similar studies on larger sample size of patients with HCV. Comparingall available protocols of HCV treatment rather than only two protocols.
Keywords: Hepatitis C Virus, chronic Hepatitis C, Ribavirin and Sovaldi therapy