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Background: Despite decades of research into these conditions, the ability of clinicians to predict preeclampsia and HELLP syndrome prior to the onset of symptoms has not improved significantly. In this study, Pregnancy Associated Plasma Protein-A (PAPP-A) was examined after the 26th weeks of gestation for early detection and prediction of complications in both severe preeclampsia and HELLP syndrome. Uterine Doppler ultrasonography, as a good predictive tool for both diseases and expected fetal outcome, was examined in all cases in this study.
Purpose: To improve the pregnancy outcome.
Patient and Methods: 50 patients suffering from either severe preeclampsia or HELLP syndrome were included in this study. Two strictly, gestational age matched groups were constructed. The 1st group consisted of 38 women who were diagnosed as severe preeclampsia. The 2nd group consists of 12 women who were diagnosed as HELLP Syndrome.
Results: The study showed that PAPP-A was significantly increased in all cases of severe preeclampsia and HELLP groups. The study showed that there was statistically significant increase in PAPP-A in HELLP group than PE while there was statistically significant increase in systolic and diastolic blood pressure in severe preeclampsia group than HELLP group.
Regarding Uterine Doppler study, this study showed that there was no statistically significant difference between severe preeclampsia and HELLP groups.
PAPP-A alone was proved to be a sensitive predictor for severe preeclampsia and HELLP syndrome. This sensitivity could be improved by combining with uterine Doppler studies. Therefore, whether PAPP-A is used alone or in combination with Doppler studies, it appears to be a promising area for future research in this field.
Keywords: HELLP Syndrome - Radio-Immuno-Assay - Doppler Ultrasonography - Biological Markers - Severe Preeclampsia