الفهرس 
Nuchal Translucency
Prenatal diagnosisOnly 14 pages are availabe for public view
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Abstract
One of the ultrasonographic markers used for
trisomy 21 screening is nuchal translucency thickness
(NT) that can be applied early in pregnancy.
Nuchal translucency is the sonographic appearance
of subcutaneous accumulation of fluid behind the fetal
neck in the first trimester of pregnancy. Only the fetal
head and upper thorax should be included in the image for
measurement of NT. A good sagittal section of the fetus,
as for measurement of fetal crown–rump length, should be
obtained and the NT should be measured with the fetus in
the neutral position.
2D Ultrasound is basically an axial image and 3D
Ultrasound is a volume and 4D Ultrasound is a volume
with time and the fifth dimension is how do you bring a
level of workflow into ultrasound, and it is basically
bordering on the sense of automation. 5D technology is a
form of automation where you go through and do a scan
and you get the results autopopulated for you. Five-
Dimensional Ultrasound included features like 5D-LB
(fetal long-bone) and 5D-NT (nuchal translucency), 5D
(fetal echo-cardiography), 5D-CNS (central nervous
system)and 5D follicle monitor.5D NT is a new software, which automatically
identifies the midsagittal view and calculate the NT
thickness using stored 3D data.
Aim of the study to evaluate the feasibility of five
dimensional nuchal translucency (5D NT) ultrasound.
The current study was conducted in the Special
Fetal Care Unit in Ain-Shams University Maternity
Hospital in the period between March 2016 and March
2017. A total of 100 women were included in the study.
Two dimensional and five dimensional ultrasound
examinations was performed with an S-W S80A Elite
(Medison Co, Ltd, Seoul, Korea) ultrasound machine by
Operator A (Dr. Rehab Mohammed) and Operator B (Dr.
Monira Ali). Then, intra- and inter- observer variability
were assessed.
Results:
In this study, 95% limits of agreement were
calculated to range from – 0.97 to 0.83, i.e. for 95% of
women, a NT thickness measurement by conventional 2D
U/S would be between 0.27 mm less and 0.13 units
greater than a measurement by 5D U/S.
Intraclass correlation coefficient, denoting the
absolute agreement between measured values by both methods, was calculated to be 0.83, which is considered
excellent correlation according to Cicchetti grading.
Mean difference between repeat measurements by
the same observer was statistically significantly lower
using 5D U/S compared to the conventional 2D U/S
(0.016 vs 0.034 mm, p = 0.01). Also, 95% limits of
agreement were narrower in case of 5D U/S compared to
2D U/S (-0.06 – 0.09 vs -0.13 – 0.19).
Mean difference between repeat measurements by
different observers was statistically significantly lower in
the 5D U/S technique compared to the conventional 2D
U/S (0.011 vs 0.09 mm, p = 0.04). Also, 95% limits of
agreement were narrower in case of 5D U/S compared to
2D U/S (-0.34 – 0.37 vs -0.22 – 0.46).
Time needed for examination was statistically
significantly longer using the 5D U/S compared to the
conventional 2D U/S. this might be attributed to the less
experience with the 5D NT thickness measurement
compared to widely known conventional 2D U/S.