الفهرس 
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Abstract
SUMMARY
hildhood Psoriasis is a chronic immune-mediated disease which may affect the skin, nails and joints. The mean age of onset of pediatric psoriasis varies from 8 to 11 years. It is estimated that about one third of psoriasis patients develop their symptoms during childhood. It is generally believed that boys and girls are quite equally affected during childhood.
The same clinical types of psoriasis are observed in children and adults, including plaque, guttate, inverse, erythrodermic, and pustular psoriasis, with the exception of napkin/genital psoriasis, which appears mainly in children younger than 2 years old. The most common type is chronic plaque psoriasis which develops primarily on the scalp, face and extensor surfaces of the elbow and knee. The scalp is the most frequently involved area.
Children suffering from psoriasis have a higher prevalence of comorbidities, including obesity, diabetes mellitus, hypertension, rheumatoid arthritis, Crohn’s disease and psychiatric disorders, compared with children without psoriasis. Psoriasis in children and adolescents can have a significant impact on quality of life by interfering with family and social relationships, school and self-esteem.
The aim of this study is to evaluate psoriasis in Egyptian children. Clinical types, associated comorbidities and quality of
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Summary
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life were assessed to determine the epidemiology of childhood psoriasis among Egyptian patients. It was conducted on 100 children with psoriasis aged less than 18 years of both sexes. The children were classified into 2 groups, group (1) included patients whose age ranged from 1 day to 10 years and group (2) included patients whose age ranged from 10 – 18 years.
Each patient was subjected to a careful history taking, including age, sex, age of onset, family history of psoriasis, primary site of appearance, triggering factors of the disease, associated autoimmune and allergic diseases, joint pain and treatment received.
General examination including associated autoimmune condition, systemic blood pressure and BMI was done for each patient. Each child was liable to careful dermatological examination to detect type and location of psoriatic lesions. Blood sample was taken from each patient to assess serum fasting blood sugar, serum cholesterol and triglycerides. PASI and CDLQI were assessed for each child to assess severity of psoriasis and its impact on QoL.
Our results revealed that childhood psoriasis has an equal gender distribution; mean age of the disease onset is 7.6 years. Trauma is the most common precipitating factor of psoriasis especially in male patients, extremities are the most frequent involved primary site of the body and plaque-type is the commonest variant. Nail pitting is the most frequent nail
Summary
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change and extremities are the commonest involved area at time of presentation. Guttate psoriasis is much higher in young children. Childhood psoriasis has a risk of associated comorbidities including diabetes mellitus, hypertension, hyperlipidemia and bronchial asthma. Obesity was observed much higher in male than female patients. Topical treatment is the first line of treatment in childhood psoriasis either alone or with other modalities. Most psoriatic children have mild form of the disease with a PASI score of less than 10% and a positive correlation was detected between PASI and CDQLI score