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العنوان
ASSESSMENT OF THE HEALTH RISKS OF THE EXPOSURE TO ENVIRONMENTAL ESTROGEN AMONG MALES \
المؤلف
Mohammed, Eman Ahmed Sultan.
هيئة الاعداد
باحث / Eman Ahmed Sultan Mohammed
مشرف / Mahmoud Serry El Bokhary
مشرف / Osama Mohamed Radwan
مشرف / Hala Ibrahim Awad Allah
تاريخ النشر
2017.
عدد الصفحات
110 p. :
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
علم الغدد الصماء والسكري والأيض
تاريخ الإجازة
29/11/2017
مكان الإجازة
جامعة عين شمس - معهد البيئة - العلوم الطبية البيئية
الفهرس
Only 14 pages are availabe for public view

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Abstract

A major challenge for life scientists in the 21st century is to understand
how a changing environment impacts all life on earth. Over the past 20
years, a great deal of attention has focused on the impact of endocrine
disruptors released in the environment on animal and human health.
Generally, endocrine disruptors have estrogenic activity. These products
interfere with hormone biosynthesis, metabolism, or action resulting in a
deviation from normal homeostatic control or reproduction. Aim: Our
primary aim was to evaluate the possible role of environmental estrogen
on sexual disturbance among males. SUBJECTS & METHODS: A
cross-sectional cohort community based study that recruited 26
apparently healthy males that agreed to participate in the study after
explained details about the study and investigation that will be done and
signed the informed consent for the study. We surveyed their
characteristics of life style, symptoms covering various systems, general
examination including blood pressure measurements, body mass index,
waist line, resting blood pressure, Venous blood samples were used for
detection of both total testosterone & plasma BuChE activity that is
measured with a Test-mate ChE Randox kit from the hydrolysis of
butyrylcholine iodide, and data were expressed as micromoles per minute
per milliliter of plasma (U/ml). Evaluation of Test-mate ChE results was
based on AChE and BuChE inhibition associated with different degrees.
RESULTS: the mean age was (36.54 ± 6.04) years with mean BMI of
(28.98 ± 5.16) kg/m2. , mean waist (102.78 ± 11.18) cm. 66.7% of the
cases were married and 13.3% have fertility problem & 20% with sexual
problem. 66.7% of the studied group use pesticide at home. The mean
serving intake of fruit & vegetables /week were (2.65 ± 2.90) serving.
CONCLUSION: Nearly all studied group had hormonal values and
AChE within the reference range. There is a negative association
between OP pesticides exposure assessed by the AchE as indicator and
serum total testosterone levels as well as with fruit & vegetables
consumption/week; whereas there is a positive association with age.
Taken together, the epidemiologic data on the environmental EDCs
suggest that there may be associations between exposure and adverse
health outcomes in men. However, the limited human data, and in many
instances inconsistent data across studies, highlight the need for further
research on these chemicals. Future longitudinal molecular epidemiology
studies with appropriately designed exposure assessments are needed to
determine potential causal relationships, to identify the most important
time windows/life stages of exposure, and to define individual
susceptibility factors for adverse effects on men’s health in response to
exposure.