الفهرس 
DIABETES MELLITUS ”DM” AND CORONARY ARTERY DISEASEOnly 14 pages are availabe for public view
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Abstract
iabetes mellitus (DM) type II is a major contributor to coronary artery disease (CAD).Also CAD is the major cause of morbidity and mortality in diabetic type II patients. Risk stratification of patients with diabetes type II is very important to plan the management and to follow the clinical status of those patients over time, this can be done non-invasively using MSCT coronary angiography.
Patients included were divided into two groups:
group I: 80 diabetic type II patients
group II: 80 non-diabetic patients.
All study groups were presenting to Kobry El kobba military hospital with symptoms suggestive of coronary artery disease (chest pain). The study evaluated the coronary plaque burden during the course of symptomatic coronary artery disease and did not include subjects free of atherosclerosis.
The aim of the study was to evaluate whether differences in the extent and composition of coronary plaques in diabetic type II patients and non-diabetic patients can be observed using MSCT coronary angiography.
We used MSCT coronary angiography to compare the plaque burden status between Diabetic type II and non-diabetic patients regarding the total plaque volume, number, distribution, type (non-calcified, mixed & calcified plaques) & presence of obstructive plaques, more over it allowed us to determine the plaque composition according to the mean density of plaques expressed in Hounsfield unit (lipid, fibrous & calcified plaques).
This study showed that diabetic patients were associated with a significantly higher coronary plaque burden and more obstructive plaques. Also, significantly more non-calcified and calcified plaques in combination with less mixed plaques were observed in patients with diabetes.
Regarding plaque composition we found that diabetic patients had significantly more lipid (vulnerable) plaques than non-diabetic patients while non-diabetic patients had significantly more fibrous plaques than diabetic patients.
Thus, MSCT can be used effectively for risk stratification of patients with diabetes type II. Also MSCT may be useful in detecting lipid plaques that are at high risk for myocardial necrosis after PCI procedure and in guiding PCI procedure in calcified and CTO lesions.