الفهرس 
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Abstract
Ethyl 2-(cyanoamino)-4-phenylPyrimidine-5-carboxylate was obtained by one pot multicomponent reaction of ethyl 3-oxo-3-phenylpropanoate, N,N-dimethylforamide dimethelacetal (DMF DMA) and cyanoguanidine. Cyanamides reacted with piperdine, morphalin, 1-(4-methoxyphenyl)piperazine, piperazine, ethylene-diamine, ortho-phenylenediamines, ortho-aminothiophenol, ortho aminophenol, benzhydrazide , ethyl 2-amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate, diethyl 2,5-diaminothieno[2,3-b]-thiophene-3,4-dicarboxylate and ethyl (3-oxopiperazin-2-yl)acetate, to give guanidine, azole, thienopyrimidine and pyrazinopyrimidine derivitives. Benzoylation reaction of cyanamide with benzoyl chloride, 2,4-dichlorobenzoyl chloride , p-tolylsulfonyl chloride, p-terephthaloyl chloride gave carboximidamides. 1-(4,6-Dimethylpyrimidin-2-yl)thiourea was stirred with phencyl bromide and p.methoxyphencyl bromide to afford 4,6-dimethyl-N-(4-phenyl-2,3-dihydro-1,3-thiazol-2-yl)-pyrimidin-2-amine and N-[4-(4-methoxyphenyl)-2,3-dihydro-1,3-thiazol-2-yl]-4,6-dimethyl-pyrimidin-2-amine. N-(4,6-Dimethylpyrimidin-2-yl)-N-(2-oxo-2-phenylethyl)-cyanamide and ethyl 2-(N-(4,6-dimethylpyrimidin-2-yl)