الفهرس 
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Abstract
Summary
A large number of Schiff base ligands and their metal complexes have been studied because of their interesting and important properties. 4-Acetyl-5,6-diphenyl-3(2H)-pyridazinone (ADP), its Schiff base ligand and its metal complexes have been studied. This field increased considerably because of the attractive observation of showing the ligand biological properties including antimicrobial and antitumor activities. For these applications, we are extending this field in synthesis of novel Schiff base complexes.
In the present work, the Schiff base ligand was prepared by the condensation of 4-acetyl-5,6-diphenyl-3(2H)-pyridazinone (ADP) as starting material, with ethylenediamine in the molar ratio 2:1 to afford the corresponding Schiff base ligand. The structure of the ligand was elucidated by elemental analyses, IR, mass, 1H-NMR and electronic spectra.
The reaction of the Schiff base ligand with various salts of some metal ions: Cu(II), Ni(II), Co(II), Fe(III), Zn(II), Cd(II), Ce(III) salts in molar ratio 1: 2 (L:M) as well as secondary ligand were carried out.
The newly prepared metal complexes of the ligand were identified by elemental analyses, IR, electronic, mass, 1H-NMR and ESR spectra as well as magnetic susceptibility measurements, molar conductivity and thermal gravimetric (TGA) analysis.
According to analytical data, all the binary complexes have 1:2 stoichiometry (ligand : metal ion) except complexes 2, 3, 5, 7, 14, 15, 19, 20, 27 and 28 which have 1:1 Stoichiometry. Ce(III) complex 29 has 2 : 1 (ligand : metal ion) stoichiometry. Moreover, the analytical data of all ternary complexes showed 1: 2: 2 stoichiometry (ligand : metal : secondary ligand; [(8-HQ), (Gly), (1,10-Phen), (Bpy) and (2-Ampy)]) except complexes 22 and 23 which showed 1:1:1 stoichiometry.
All binary metal complexes exhibited octahedral geometry except complexes 2, 6, 14 and 29.
Cu(II) complexes 2 and 6 exhibited square planar geometrical arrangements, while Ni(II) complex 14 has tetrahedral geometry. Ce(III) complex 29 exhibited octa-coordinated arrangement.
All the ternary metal complexes revealed an octahedral geometry.
Thermal gravimetric analysis (TGA) was performed for some complexes of the Schiff base ligand. Thermodynamic parameters (ΔG, ΔH, ΔS and Ea) of the metal complexes were calculated using Coats-Redfern method and standard thermodynamic equations, and this was performed using the thermal degradation of the solid complexes using TGA curves.
The ligand and its metal complexes were screened for their antimicrobial activity against Staphylococcus aureus and Bacillus subtilis as Gram-positive bacteria, Escherichia coli and Salmonella typhimurium as Gram-negative bacteria, Candida albicans and Aspergillus fumigatus as fungal strains. The antitumor activity of the Schiff base ligand and some of its metal complexes was investigated against HepG2 cell line.