الفهرس 
Pain and InflammationOnly 14 pages are availabe for public view
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Abstract
Quinazolinones constitute an integral part for many biologically active natural products in living tissues such as febrifugine and Luotonin A which are alkaloid derivatives.
Quinazoline and quinazolinone derivatives are important classes of these heterocyclic structures.
They are composed of fused benzene and pyrimidine rings having wide biological activities especially anti-inflammatory, anticancer, antimicrobial, anticonvulsant, analgesic, antiviral and other miscellaneous activities. Their therapeutic efficacy against inflammation has been related to their ability to inhibit prostaglandin biosynthesis. Quinazolinone derivatives linked to 1,2,3-triazole or isoxazole ring have a great biological and medicinal significance. \Motivated by these facts and as a continuation of our research on heterocyclic chemistry aiming to find new structure leads which might be of value for development of new more potent anti-inflammatory agents, with higher safety profile, the present investigation was directed to design, synthesize and biologically investigate a new series of quinazolinone derivatives as anti-inflammatory and anticancer agents.
Chapter 1: Introduction
It represents a brief literature survey on biologically active substituted quinazolinone derivatives, exhibiting anti-inflammatory, analgesic, anticancer, antiviral, and antifungal. Also discussed is the biological activity of 1,2,3-triazole and isoxazole derivatives and the click chemistry employed for their synthesis focusing on the recent researches.
<Chapter 2: Research objectives It clarifies the goal of the present work and the rationale upon which the newly suggested compounds are designed.
<Chapter 3: Discussion This chapter deals with results and discussion of the synthesis, biological evaluation and molecular modeling of the target compounds.
<This chapter is divided into three parts.