الفهرس 
AIM OF THE WORKOnly 14 pages are availabe for public view
Abstract
The fact that several quinazolinone derivatives proved to possess antimicrobial and cytotoxic activities, promoted the synthesis of new potential cytotoxic and antimicrobial agents.
<The designed compounds contained quinazolin-4(3H)one ring system bearing diverse open chains and substituted fused 5-membered heterocyclic rings. The selected chains as well as the built-in heterocyclic rings have been chosen to fulfill structure requirements for cytotoxic and antimicrobial activity. Studies on the synthesis of the desired compounds, their spectral analyses as well as their evaluation for cytotoxic and antimicrobial activity, are presented as the main text of this thesis. They are classified in accordance with their appearance in the thesis as follows:
<Chapter 1: Introduction It represents a brief literature survey on biologically active substituted quinazolin4(3H)one derivatives that include anticancer, antiviral, antimicrobial, analgesic, antiinflammatory, cardiovascular, anticonvulsant, antihistaminic, antioxidant and antidiabetic drugs.
<Chapter 2: Aim of the work It clarifies the goal of the present work and the rationale upon which the newly suggested compounds were designed.
<Chapter 3: Discussion It discusses the basic concepts of the experimental methods adopted for the synthesis of the target compounds.
It also investigates the structural elucidation of the synthesized compounds by elemental analyses and various spectroscopic techniques (IR, 1H-NMR, 13CNMR and Mass spectra).