الفهرس | Only 14 pages are availabe for public view |
Abstract SUMMARY hildhood obesity has reached epidemic levels in developed as well as in developing countries. Overweight and obesity in childhood are known to have significant impact on both physical and psychological health. Obesity in males, particularly when central, is associated with lower total testosterone [TT], free testosterone [FT] and sex hormone-binding globulin [SHBG], and a greater decline in TT and FT with increasing age compared with lean males. This study was a cross-sectional, case-control study conducted on 60 Egyptian obese adolescents males collected from the Pediatric Obesity Clinic, Pediatrics Hospital, Ain Shams University, the Pediatric Obesity Clinic, Pediatrics Hospital, Zagazig University and 3 high schools in Zagazig. Sixty Age matched males without depression or obesity were included to serve as controls and were collected from 3 high schools in Zagazig. All these adolescents were subjected to full history taking, full clinical examination, laboratory investigation (free testosterone, estradiol, FSH and LH), Tanner staging, blood pressure measurement and psychological assessment for depression using Center for Epidemiological Studies Depression Scale for Children (CES-DC), Children’s depression inventory (CDI) and Mini International Neuropsychiatric Interview for Children and Adolescents (MINI-KID). C Summary 145 The study revealed that obesity is associated with higher incidence of depression in adolescent males where (60%) of obese adolescent males had mild depression and (6.7%) of them had moderate depression, while all non obese adolescent males (100%) were not depressed. Also, there was a significant difference in mean free testosterone levels between obese adolescents with depressive symptoms and obese adolescents without depressive symptoms where the mean of free testosterone levels was lower in obese adolescents who had the following depressive symptoms: feeling depressed, eating disorders, sleeping disorders, feeling restless, feeling guilty, poor concentration and suicidality, while the mean free testosterone level was higher in obese adolescents who had the following depressive symptoms: loss of interest and feeling tired. Also, there were negative significant correlations between mild, moderate depression (according to CDI) and hormonal levels of free testosterone in obese adolescents males and there were significant negative correlations between free testosterone level and the following depressive symptoms (according to MINI-KID module A); feeling depressed, eating disorders, sleeping disorders, feeling restless, feeling guilty, poor concentration and suicidality, while there were significant positive correlations between mean free testosterone level and the following depressive symptoms; loss of interest and feeling tired |