الفهرس 
Table of Contents
Epidemiology of obesityOnly 14 pages are availabe for public view
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Abstract
Introduction: The prevalence of obesity has been increasing uncontrollably over the last two decades. While many factors are involved in the development of obesity, dietary fat has been proposed as one of the main causal factors that results in disrupted energy homeostasis by inducing both central and peripheral insulin resistance. Exenatide might decrease fat pad mass by reduced formation of new adipocyte -#102;-#114;-#111;-#109; precursor cells (adipocyte differentiation) or decreased adipocyte size due to fat storage (adipocyte hypertrophy). PPC/DC was emerged as a nonsurgical alternative for fat removal and treatment of obesity. Aim of the work: To evaluate the anti-obesity activity of centrally acting insulin sensitizer drug (Exenatide) versus peripheral lipolytic therapy (PPC/DC) and to judge relative importance of hypothalamic control of obesity. Method : This study was conducted on seventy (70) male Sprague dawley rats, divided into 5 groups., 14 rats in each. Lean control group, Non treated HFD -#103;-#114;-#111;-#117;-#112; Rats were fed HFD for 16 weeks. Exenatide treated high fat diet group. Rats were received subcutaneous injection of exenatide at a dose of 10μg/kg body weight once daily for four weeks, PPC/DC treeatd high fat diet -#103;-#114;-#111;-#117;-#112; Rats were received subcutaneous injection of PPC/DC at a dose of 600 μL once weekly for 4 weeks and Exenatide and (PPC/DC) treated HFD group. All the rats were monitored daily for food intake and body weight, HOMA index, TNFα, serum MDA, GSH and insulin receptor (IR) gene expression in hypothalamus and liver. Results : High fat diet for 16 weeks produced rapid weight gain, hyperglycemia, associated with down regulation of insulin receptor mRNA gene expression in hypothalamus and liver. Exenatide alone or combined with PPC/DC lipolytic therapy caused significant decrease in food intake, body weight and upregulation of IR gene expression. Conclusion : Clinical studies should also be conducted to evaluate the potential anti-obesity effect of combination treatment of exenatide with PPC/DC in patients with obesity.