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العنوان
The Relation between Serum Ascorbic Acid Concentration and Preterm Premature Rupture of Membranes /
المؤلف
Mohamed, Karim Mohamed Ezz El Din
هيئة الاعداد
باحث / كريم محمد عزالدين محمد
مشرف / شريف محمد حبيب
مشرف / محمد حسين مصطفي
تاريخ النشر
2017.
عدد الصفحات
105.p :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
أمراض النساء والتوليد
تاريخ الإجازة
1/1/2017
مكان الإجازة
جامعة عين شمس - كلية الطب - Obstetric and Gynecology
الفهرس
Only 14 pages are availabe for public view

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Abstract

Premature rupture of membrane (PROM) is defined as rupture of membranes before the onset of labor, while rupture of fetal membranes before 37 weeks gestation is defined as preterm premature rupture of membranes (PPROM). It is a problem that complicates approximately 10 % of all pregnancies. PROM is usually associated with significant perinatal and maternal morbidities.
Role of vitamin c in the integrity of fetal membranes was studied due to its well described role in the biosynthesis of collagen, the main structural constituent of chorioamnotic membrane.
Vitamin C reaches the avascular fetal membranes through the maternal circulation to the decidual side.
Vitamin C deficiency during pregnancy could lead to PROM by affecting collagen metabolism and its deposits in fetal tissues, including the chorioamnotic membranes.
It has been suggested that maintaining adequate vitamin C status could help to reduce incidence of PROM.
This case-control study was conducted to evaluate the relation between vitamin c and PPROM during the period from January 2016 and November 2016. 60 pregnant women between 28 to 37weeks of gestation were the subject of the study.
The 60 women were divided into two groups, each group consisted of 30 women according to presence or absence of rupture of membranes: group (1) study group with rupture of membranes and group (2) control group without rupture of membranes. The diagnosis established by physical examination that identified the leakage of amniotic fluid through the cervix by sterile cusco examination and confirmed by pelvic u/s. the gestational age was calculated by Naegle’s formula.
Blood samples were obtained from them to detect the ascorbic acid level.
This study showed highly statistically significant difference between both groups according to vitamin C (ascorbic acid) level, as the levels of serum ascorbic acid were higher among non PPROM group than the levels among PPROM group
This study showed no statistically significant difference between the women of the studied groups according to age, GA and temperature.
There was significant correlation between GA and vitamin C level among PPROM group.
There was no significant correlation between vitamin C level and age, temperature, CRP and TLC among PPROM group.
Finally, our study found highly statistically significant difference between parity and age among PPROM group as parity increases with increasing of age, and no statistically significant difference between parity and (GA, temperature and Ascorbic acid) among the same group.
The major finding in our study that serum ascorbic acid level has a strong relation with the incidence of PROM, as increased serum ascorbic acid level strengthens the fetal membranes and decreases probability of PROM.
Keywords: Serum Ascorbic Acid; PROM