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Abstract Acute kidney injury (AKI) is generally defined as an abrupt and sustained decline in renal function, causing a steady accumulation of nitrogenous and non nitrogenous products and toxins, with rapid development of fluid, electrolyte and acid-base disorders.The incidence and mortality rates are high and the search for effective treatment continues(Lisowska-Myjak, 2010.The effective protection against the consequences of the disease, based upon its early detection (Mishra,2004).Human neutrophil gelatinase-associated lipocalin (NGAL) was originally identified as a 25-kDa protein. It is normally expressed at very low levels in several human tissues. NGAL expression is markedly induced in injured epithelia. It seems to be one of the earliest markers in the kidney after ischemic or nephrotoxic injury in animal models(Schmitt-Ott, 2005). The aim of this study was to evaluate the utility of neutrophil gelatinase-associated lipocalin (NGAL) assessment as an aid in the early risk evaluation for acute renal failure development in intensive care patients. The work included 25 patients as group I (the diseased group), and25 persons as group II(the control group). |