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العنوان
Correlation Between Serum Neopterin And
Response To Treatment of chronic
Hepatitis C Virus Infection /
المؤلف
Eid,Essam Lotfy Abd-Elhamed.
هيئة الاعداد
باحث / Essam Lotfy Abd-Elhamed Eid
مشرف / Rawia Abd El-Salam Ibrahim Elfiky
مشرف / Noha Abd El Razek El Nakeeb
مشرف / Mohamed Lotfy Soliman
تاريخ النشر
2016
عدد الصفحات
233p.;
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
الطب الباطني
تاريخ الإجازة
1/1/2016
مكان الإجازة
جامعة عين شمس - كلية الطب - الطب الباطنى
الفهرس
Only 14 pages are availabe for public view

from 233

from 233

Abstract

epatitis C virus (HCV) infects up to 180 million people
worldwide and is a major cause of chronic liver disease,
cirrhosis, and hepatocellular carcinoma. The current treatment,
based on the combination of peginterferon a (pegINF-a) and
ribavirin, leads to a sustained virological response (SVR) in
about 40–50% of patients with the HCV genotype 1 or 4 and in
about 80% of those with the genotype 2 or 3.
The aim of this study was to assess serum neopterin
concentrations as a marker of virological response to antiviral
therapy by peginterferon a combined with ribavirin in Egyptian
patients with hepatitis C (genotype 4). Neopterin is a pteridine
derivative produced by monocytes and macrophages under the
control of gamma-interferon and released from T-cells by the
activation of the cellular immune system. Neopterin serum
level above 10 nmol/L is regarded as elevated.
60 cases were included in this study.
Cases were divided into three groups:
 group I: 20 patients with early virological response
 group II: 20 patients null responders.
 group III: 20 normal persons (as control group).Attending to the hepatology and virology treatment center
of Damanhour Medical National Institute.
After evaluation of each patient and applying
exclusion criteria,and after full history taking, complete
clinical examination, laboratory investigations, abdominal
Ultrasound, liver biopsy, neasurement of serum levels of
Neopterin by ELIZA technique before and at week 12 of
treatment.
Neopterin is a more sensitive marker for severity of
liver disease than established markers of inflammation, its
concentration usually correlate with the extent and activity of
the disease, and are also useful to monitor during therapy in
these patients.
Measurement of neopterin concentrations in body fluids
can be a reliable indicator of the cellular immunological
response in hepatitis C virus infection more over enhanced
concentration of neopterine have been shown to have
prognostic significance and monitoring stimulatory therapy.It is
suggested that serum neopterin levels can be used as a
significant parameter for the differential diagnosis of noninfectious hepatitis and viral hepatitis.
Neopterin might be used as a marker to predict the
response to antiviral therapy (pegylated-interferon- (pegIFN)combined with ribavirin) in HCV patients. A “neopterin test” is
cost-effective, helpful in both HCV1 and HCV4 and HCV2 and
HCV3 genotypes, and less invasive than liver biopsy. Mean
and median pretreatment Neopterin concentrations were lower
in patient with sustained virological response than in null
responder.
Our study revealed that:
Serum neopterin level was significantly elevated in
patients with chronic hepatitis C virus compared to healthy
control individuals.
Neopterin level was found with high significant
difference between the Early virological Responder and null
responders. These results indicate that response rate for
treatment with INF and Ribavirin was significanty correlated
with neopterin levels. Among patients with neopterin levels
of <15.8 nmol/L response rate were about two folds for all
patients genotype HCV4 and Patients with neopterin levels
>15.8 nmol/L had the lowest rate of response (genotype 4).