الفهرس 
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Abstract
SUMMARY
2(3H)-Furanones represent an important type of five-membered
heterocyclic systems. The importance of these compounds stems
from facile opening of the lactone ring with both nucleophilic and
electrophilic reagents to give acyclic product. These acyclic products
are the precursors of a wide variety of synthetically and biologically
important heterocyclic systems e.g. pyridazinones, oxadiazoles,
triazoles, isothiazolones…etc.
In this investigation, ring transformation of pyrazolyl
substituted 2(3H)-furanone into novel fused and unfused nitrogen
containing heterocycles, and the behavior of the synthesized
compounds against highly pathogenic avian influenza H5N1 are
studied.
The original work of this thesis consists of three main parts:
Part 1: In this part, the acid hydrazide (1) was obtained from
hydrazinolysis of 2(3H)-furanone bearing pyrazolyl moiety at
position-3.
The reactions of the acid hydrazide (1) with different carbonyl
compounds were studied. Thus, when reacted with acetylacetone,
ethyl acetoacetate or ethyl cinnamate gave the pyrazole derivatives
(4), (6) or (8) respectively. On the other hand, the reaction with
acetonylacetone led to the formation of the pyrridazine derivative
(2). The pyrazoldione derivative (9) was obtained via refluxing (1)
with diethyl malonate in ethanol.
Summary
II
The phthalazinedione derivative (10) was obtained upon
treatment the acid hydrazide with phthalic anhydride.
The open-chain Shciff base products (12) and (14) were
obtained upon condensation of the acid hydrazide with benzil and panisaldehyde
respectively.
Reaction of the Schiff base product (13) with thioglycolic acid
gave the thiazolidinone product (14)
The chemical transformations in this part can be represented
by the two Schemes (A) and (B).