Search In this Thesis
   Search In this Thesis  
العنوان
Investigating the Relationship between Estrogen and Short Stature among Young Females in Gaza /
المؤلف
Rashed, Hussam Samir Ragab.
هيئة الاعداد
باحث / Hussam Samir Ragab Rashed
مشرف / Wael M. El-Sayed
مشرف / Nehad Rafiq El-Yazji
مناقش / Nehad Rafiq El-Yazji
تاريخ النشر
2017.
عدد الصفحات
P
P 311. :
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
علم الحيوان والطب البيطري
تاريخ الإجازة
1/1/2017
مكان الإجازة
جامعة عين شمس - كلية العلوم - قسم علم الحيوان
الفهرس
Only 14 pages are availabe for public view

from 168

from 168

Abstract

Investigating the relationship between estrogen and short stature among young females in Gaza
Key words: Estradiol, Growth hormone, insulin like growth factor-1, insulin like growth factor binding protein-3, FSH, short stature, Gaza–Palestine.
Background and aims: Growth is a complex process that involves integration of genetic potential, functioning endocrine system, nutritional status, effects of chronic illnesses or diseases, and physical activity level. A disturbance at any point of these levels may affect growth adversely resulting in short stature. Early diagnosis and treatment is most of the time rewarding. Sex steroids are of great importance in normal growth, especially during puberty, when they control initiation, maintenance and cessation of the pubertal growth spurt. The sex steroids act both locally in the growth plate and systemically via the growth hormone (GH)/ insulin-like growth factor 1 (IGF-1) axis. This study aimed to examine the utility of estradiol, GH, IGF-1, IGFBP-3 and other factors for diagnosing short stature in young females.
Methods: Non-experimental case control study design was used to collect data from 90 girls with short stature (case group), and 90 girls with normal stature (control group). Self-report structure interview. Samples were collected from secondary school girls, Gaza, Palestine for assessment of estradiol, ghrelin, osteocalcin, FSH, LH, prolactin, progesterone, insulin, GH, IGF-1, and IGFBP-3 in addition to chemistry profile (cholesterol, triacylglycerols, HDL-C, LDL-C, Ca+2,
 Abstract
2
P, Mg+2, glucose and liver function tests). SPSS version 22 was used for statistical analysis.
Results: The results showed that there was no statistically significant correlation between estradiol and height of case girls. However, there were highly significant reductions in stature, body weight, GH, IGF1, IGFBP3, and FSH levels in case girls compared to control. Significant elevations in the activities of ALT and ALP were reported in cases compared to controls. In addition, there was a significant correlation between insulin and height and between IGF1 and ghrelin in case girls. In addition, there was a significant correlation between ghrelin and insulin in both case and control girls.
Conclusions: Results of this study suggested that estradiol is not associated with short stature at this time of age in the target group. Growth related hormones could serve as a biomarker in the diagnosis of short stature in girls aged 15-16 years. Elevations in ALT and ALP without changes in phosphorus suggest liver problem and needs further investigation and attention. The predominant type of short stature is constitutional delay of growth and development (CDGD). This means a delay in the puberty and a consequent delay in the growth spurt associated with some psychological disturbances, self-esteem, and social withdrawal.