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العنوان
Comparative Study of Ethmoid Bone
Osteitis and Tissue Eosinophilia in
different Types of chronic Rhinosinusitis /
المؤلف
AbdAllah,Mohamed Hassan.
هيئة الاعداد
باحث / Mohamed Hassan AbdAllah
مشرف / Osama Mahmoud Ibrahim
مشرف / Yasser Mohamed Fawzy El Beltagy
مشرف / Naglaa Samir Ahmed
تاريخ النشر
2016
عدد الصفحات
169p.:
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
الحنجرة
تاريخ الإجازة
1/1/2016
مكان الإجازة
جامعة عين شمس - كلية الطب - أمراض الأذن والأنف والحنجرة
الفهرس
Only 14 pages are availabe for public view

from 189

from 189

Abstract

It has been observed that CRS is becoming more
resistant to common treatment. Moreover, the chronic
nature makes the situation more difficult with regard to
diagnosis and management. The latter often fails, and
long-term antibiotic administration is often inadequate
to eradicate disease that gradually affects patients‟
quality of life.
Chronic rhinosinusitis (CRS) is a disease
characterized by inflammation of the mucosa lining the
paranasal sinuses; however, recent evidence also indicates
the involvement of the sinus bones in the inflammatory
process. In ongoing research to better characterize the
pathogenesis of CRS with respect to reasons for failure,
mucosa continues to receive the majority of attention,
including factors such as the local immune response and
biofilms. On the other hand, the role of osteitis, or
inflammation involving bone, is much less extensively
studied.
“Osteitis” is characterized by varying degrees of
increased osteoblastic-osteoclastic activity, resulting in
disruption of organized lamellar bone and formation of immature woven bone. Expansion of the haversian canal
system with entry of inflammatory infiltrate in an increased
vascular network has been demonstrated, wherein osteitis
may act as a potential pathway for spread of mucosal disease.
The current study assess the presence of osteitis
in ethmoid bone and tissue eosinophilia in nasal
mucosa of patients with chronic rhinosinusitis, with
nasal polyps, without nasal polyps and allergic fungal
sinusitis to find out if there is correlation between
etmoid bone osteitis, tissue eosinophilia and severity of
chronic rhinosinusitis.
Patients were evaluated clinically by SNOT 22
score, radiologically by Lund-Mackay score and
biopsies were taken from ethmoid bone and mucosa
and assessed histopathologically.
As regard results of specimen under LM;
seventy five specimen were examined from three study
groups that show osteitis in 92% with more severe
affection in AFS patients, there was variable degree of
mucosal affection and tissue esinophilia and there was
strong correlation between mucosal and bony grading.The current study show correlation between
SNOT 22 score clinically and Lund-Mackay score
radiologically.
There is strong correlation between osteitis and
tissue eosinophilia
Regarding 10 control patients, specimen show
30% osteitis and remaning normal bone.
Definition of chronic rhinosinusitis shoud be
modified from only sinus mucosal affection to include
bony osteitis.
Further studies are needed to search for etiology
of osteitis in CRS patients, modification of FEES for
eradication of osteitic bones and possible medical
treatments for osteitis to prevent recurrent
rhinosinusitis.