الفهرس | Only 14 pages are availabe for public view |
Abstract SUMMARY In the present study, the aquatic extracts of Aloe vera, Azadirachta indica, and Moringa oleifera separately/mixedly ameliorated the hepatotoxic effect of carbon tetrachloride and restore the antioxidant status after 36 days of treatment. Administration of extracts orally substantially restored liver enzymes, erythrocyte glutathione content, and plasma malondialdehyde to the normal level along with improvement of the histopathological features of the injured liver cells. Treatment with Moringa mono extract, Aloe vera mono extract, (Aloe vera and Moringa) bi extract, (Moringa and Neem) bi extract, Neem mono extract, (Aloe vera and Neem) bi extract, and (Aloe vera, Moringa, and Neem) tri extract for 36 days were more effective in restoring liver enzymes and improving the histopathological features of liver cells than the 18 days duration. The Neem mono extract and the (Aloe vera and Neem) bi extract had the least protective effect on hepatotoxicity as they relieved the congestion and hepatocyte atrophy. This result matches the investigated biomarker results. As Neem mono extract took longer time for complete amelioration of MDA comparing to the normal control. However, there was still vacuolar degeneration of hepatocytes after 36 days of treatment, 85 which could be enhanced if the treatment extended than 36 days. These results emphasize that administration of Aloe vera gel, Moringa and Neem leaves aquatic extracts could protect against carbon tetrachloride induced hepatotoxicity. Further studies are recommended to decrease the treatment duration by increasing the concentration of the used extracts and investigate any side effects |