الفهرس 
Carbon Monoxide PoisoningOnly 14 pages are availabe for public view
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Abstract
Background: Carbon monoxide poisoning is considered to be one of the leading causes of death worldwide and delayed neurological sequelae (DNS) are the most frequent form of morbidity. Clinical features of the delayed neurological sequelae included cognitive impairments, affective disorders and abnormal neurological signs that developed between 2-40 days after acute carbon monoxide (CO) poisoning. Predicting development of DNS during the acute phase of acute carbon monoxide would help in making treatment decision by such means as identifying cases to which HBO therapy should be actively administered and setting an appropriate period of hospital treatment and also consider appropriate follow up period. The aim: of this study was to assess usefulness of S100B protein for predicting (DNS) in acute carbon monoxide toxicity and its correlation to clinical picture, other neurobiochemical markers and CT finding after acute carbon monoxide poisoning. Method & Subjects: This case control study was conducted on 40 patients of both sexes who were admitted to the Poison Control Center (PCCA), Ain Shams University Hospitals, with acute CO intoxication, in the period starting from 1st of December 2013 to 30th of June 2015. Patients in this study were divided into three groups: group 1: Patients with delayed neuropsychiatric syndrome (DNS), group 2: Patients without delayed neuropsychiatric syndrome (DNS) and group 3: 20 healthy volunteers served as control group. Serum S100B protein and Neuron specific enolase (NSE) initially when the patients presented to the emergency room and then at 12 and 24 hours were assessed for all groups of patients. Blood samples also underwent analysis for measurement of (Arterial blood gases (ABG), Carboxyhemoglobin level (COHb), blood glucose, renal functions, serum Creatine Phospho kinase (CPK) and CPK-Mb). Results: There was significant increase in serum S100B protein and serum NSE levels initially, at 12 hours and 24hours in DNS group when compared with non DNS and control groups after acute carbon monoxide poisoning. Conclusions: S100B protein levels initially, at 12 and 24 hours after acute carbon monoxide poisoning could be employed as a useful marker for predicting clinical severity, development of delayed neurological sequelae and mortality in patients with carbon monoxide poisoning.
Keywords: CO: carbon monoxide, DNS: delayed neurological sequelae, NSE: Neuron specific enolase.