الفهرس 
Idiopathic Interstitial Pneumonia
Idiopathic pulmonary fibrosisOnly 14 pages are availabe for public view
Abstract
Idiopathic interstitial pneumonias (IIPs) are interstitial
lung diseases of unknown etiology that share similar
clinical and radiological features and are distinguished
primarily by the histopathologic patterns on lung biopsy.
Diagnosis is based on history, physical examination, highresolution CT imaging, pulmonary function tests, and lung
biopsy. Treatment varies by subtype. Prognosis varies by
subtype and ranges from excellent to nearly always fatal
(ATS and ERS, 2002).
Measurements that can be made periodically to
objectively assess changes in physiologic function over
time include formal dyspnea assessment tools, the forced
vital capacity (FVC), diffusion capacity of the lung for
carbon monoxide (DLCO), and the 6-minute walk test (6-MWT) distance and oxyhemoglobin saturation change. A
test of the diffusing capacity of the lungs for carbon
monoxide (DLCO) is one of the most clinically valuable
tests of lung function. DLCO measures the ability of the
lungs to transfer gas from inhaled air to the red blood cells
in pulmonary capillaries reflecting arterial deoxygenation
(Macintyre et al., 2005). This prospective study was done to study the
correlation between 6 minutes walking test and DlCO in
patients with Idiopathic Interstitial Pneumonitis admitted at
Ain Shams Hospital as an indicator for arterial
deoxygenation.
The study group consisted of 25 outpatients (13 were
males &12 females), with mean age 52.2 ± 12.39.
The following parameters were fulfilled for all
the patients:
1. Full history taking.
2. Thorough clinical examination.
3. Chest X-ray
4. High Resolution Computerized Tomography (HRCT)
5. Full Spirometric study
6. DLCO before 6 minutes walk test
7. Oxygen Saturation using Pulse Oximetry before and
after 6 -MWT
8. 6 minutes walk test (6 -MWT)
The results of this study were:1- There was a +ve correlation between DLCO defect and
resting Spo2 in a group of patients with mild DLCO
defect, there was a +ve correlation between DLCO defect and post exertion Spo2 in a group of patients
with mild DLCO defect, there was a –ve correlation
between DLCO defect and difference saturation Spo2
in a group of patients with mild DLCO defect.
2-There was a +ve correlation between DLCO defect and
Resting Spo2 in a group of patients with moderate
DLCO defect, There was ws a +ve correlation
between DLCO defect and Post exertion Spo2 in a
group of patients of moderate DLCO defect, there was
a –ve correlation between DLCO and Difference
saturation ( resting and post exertion Spo2 ) in a group
of patients with Moderate DLCO defect.
3-There was a + ve correlation between DLCO defect and
Resting Spo2 in a group of patients with severe DLCO
defect, there was a + ve correlation between DLCO
defect and Post exertion Spo2 in a group of patients
with severe DLCO defect, there was a – ve correlation
between DLCO defect and Difference saturation
(Resting and Post exertion Spo2) in a group of patients
with severe DLCO defect.
4-There was a + ve correlation between DLCO defect and
Resting Spo2 in all the patients of the studied group,
there was a – ve correlation between DLCO defect and Post exertion Spo2 in all patients of the studied group,
there was a + ve coreelation between DLCO defect
and Difference saturation (resting and post exertion
Spo2) in all patients of the studied group.
5-The cutoff value of DLCO defect was < 7.6 with
sensitivity of 86% and specificity of 88% within mild
DLCO defect, >7.6 with sensitivity of 88% and
specificity of 90% within moderate DLCO defect and
>10.5 with sensitivity of 84% and specificity of 87%
within severe DLCO defect.