الفهرس 
EndometriosisOnly 14 pages are availabe for public view
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Abstract
Introduction:
Endometriosis is an estrogen-dependent disease
affecting 8% to 10% of females of reproductive age. It is
diagnosed in 71% to 87% of females with chronic pelvic
pain and in 30% of women with infertility. Propranolol
inhibits angiogenesis, which plays a critical role in the
pathogenesis of endometriosis and could be used as a
treatment modality to avoid surgery.
Aim of the study:
The aim of this study was to investigate whether
propranolol has an inhibitory effect on the angiogenesis of
endometriosis in an experimental rat model.
Materials and method:
Twenty-four female, non-pregnant Wistar albino rats
were used to create a model for the experimental induction
of endometriosis. Endometriosis was surgically induced in
rats by transplanting an autologous fragment of endometrial
tissue onto the inner surface of the abdominal wall. After
four weeks rats underwent a second laparotomy to examine
the endometrial implants for size and viability .Rats were
divided into treatment (propranolol) and control groups. The rats in the control group (n = 10) received daily
intraperitoneal instillation of 2 mL of saline as a vehicle
solution. The injections were administered at the same time
each day for 3 weeks. Rats in the treatment group (n = 10)
were given 10 mg/kg of intraperitoneal propranolol daily.
At the end of the 3 weeks, all rats were euthanized.
Measurement of the ectopic endometriosis,
Histological and immune-histopathological evaluation was
conducted.
Results:
Treatment with propranolol reduced the size of the
ectopic endometriosis. Levels of VEGF were mild in the
treated group compared with sever levels in the control
group.
Recommendation:
Beta blockers including propranolol could be one of
the promising treatment modality for endometriosis.
Further investigations are required to pave the way for
clinical application.