Search In this Thesis
   Search In this Thesis  
العنوان
Preparation, physicochemical characterization and antitumor
activity of metal complexes of some new hydrazone oxime
Preparation, physicochemical characterization and antitumor
activity of metal complexes of some new hydrazone oxime
ligands /
المؤلف
ABOU EL FADL, NAHLA ABD EL HALIM AHMED,
هيئة الاعداد
باحث / NAHLA ABD EL HALIM AHMED ABOU EL FADL
مشرف / Abdou Saad El-Tabl
مناقش / Moshira Mohamed Abd Elwahed
مناقش / Abdou Saad El-Tabl
الموضوع
Cancer Biological properties of some metal complexes Biological properties of cobalt Oximes and Hydrazones
تاريخ النشر
2015 .
عدد الصفحات
263 p. :
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
Inorganic Chemistry
تاريخ الإجازة
9/8/2015
مكان الإجازة
جامعة المنوفية - كلية العلوم - قسم الكيمياء
الفهرس
Only 14 pages are availabe for public view

from 16

from 16

Abstract

This work is composed of four main chapters. The first chapter: introduction
In this chapter, a literature survey was carried out and included the following of
items:-
a) Introduction about medicinal inorganic chemistry.
b) Introduction about cancer and cancer chemotherapy.
c) Metal ion complexes as anticancer agents:-
i) Development of a new anticancer agent.
ii) Classes of metal based pharmaceuticals.
d) Antiinfective metal ion complexes.
e) Biological properties of some metal complexes.
f) Introduction about importance of hydrazone oximes.
g) Importance of oximes and modes of bonding of oxime in
metal complexes.
h) Defintion, nomenclature and preparation of hydrazones.
i) Importance of hydrazones and their metal complexes in the
following fields of applications:-
1- Biological application: Antitumor, anti-mycobacterial and antimicrobial
activity.
2- Pharmaceutical application: Anti-inflammatory activity, hydrazones in
treatment of iron overload diseases, antimalarial, anti-trypanosomal and
anti- convulsant. 3- Catalytic applications: In many fields such as some polymerization
processes and some chemichal reactions.
4- Analytical applications: Such as separation and determination of traces
of metals and determination of some species in pharmaceutical
formulations.
he second chapter: review of literature
eview of literature on hydrazones, oximes and hydrazone oximes.
his chapter included the following items:
1- Aliterature survey was carried outon hydrazones which include
bidentate, tridentate, teradentante, pentadentate, hexadentate, octadentate
and nonadentate hydiasone ligands and their corresponding metal
complexes. Analytical applications: Such as separation and determination of traces
of metals and determination of some species in pharmaceutical
formulations.
econd chapter: review of literature
of literature on hydrazones, oximes and hydrazone oximes.
apter included the following items:
Aliterature survey was carried outon hydrazones which include
bidentate, tridentate, teradentante, pentadentate, hexadentate, octadentate
and nonadentate hydiasone ligands and their corresponding metal
complexes.
Aliterature survey was carriedouton oximes which include types of
oximes: simple, carbonyl, vicinal, phenol, hydroxy, imine, pyridine and
amine oximes.
Literature surveyand some examples on hydrazone oximes.