الفهرس 
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Abstract
SUMMARY
elicobacter pylori is now known to cause peptic ulcers, gastric
adenocarcinoma and gastric MALT lymphoma.
This study was conducted to 36 dyspeptic patients showed positive
endoscopic findings where the biopsies were obtained from their antral
gastric mucosa. H. pylori isolates were detected in 58.5% of the patients
complaining from duodenal ulcer, in 25% of cases with gastric ulcer and
in 22% of patients with gastritis and duodenitis.
Some H. pylori negative cases included in this study showed other
microorganisms in their specimens namely: Staphylococcus sp., yeast,
Bacillus sp. and other gram negative rods bacteria.
All 15 H. pylori isolates were resistant to metronidazole and
amoxicillin while tetracycline and levofloxacin were found to be the most
effective tested antibiotics. Concerning amoxicillin /clavulanic acid 53.5%
of isolates were resistant, 46.9% were intermediate and no sensitive ones,
while the resistance to clarithromycin was 86.6%.
This study aimed to detect the antimicrobial activity of some
medicinal plant extracts against isolated H. pylori strains. The plants
conducted to investigate their anti-H. pylori were; Cinnamomum
zeylanicum Nees (cinnamon), Thymus vulgaris L. (thyme), Syzygium
aromaticum Ranee Prakash (clove), Allium sativum L. (garlic) and
Anethum graveolens L. (dill). The microbiological study carried out by
agar diffusion method and and revealed that all tested plant essential oils
and other extracts had anti-H.pylori activity but with variable degrees.
H
Summary
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The study showed that the anti-H.pylori activity of cinnamon oil and
thyme oil had strong anti-H. pylori activity. The mean inhibition zone (MIZ) of
both cinnamon oil and thyme oil were about 30 mm, also the MIC of both
cinnamon oil and thyme oil were between 1.56% and 6.25% (v/v).
In contrast, garlic oil (MIZ =15.40 mm and the MIC was 50% v/v)
had lower activity than all other tested plant oils. While dill oil and clove
oil showed moderate activity.
The present work revealed that the methanol extract of cinnamon
was high and had much higher anti-H.pylori activity than aqueous extract
of cinnamon. In contrary, the methanol extract of thyme was comparable
to the thyme aqueous extracts where their activities were low.
Concerning the antimicrobial activity of the garlic extracts, the nhexan
extract had high activity and was more active as anti-H. pylori than
aqueous extracts that had moderate activity.
The methanol extract of dill had low activity but aqueous extracts
had moderate activity.
The obtained results revealed that the methanol extract of clove
had high activity but the aqueous extracts had moderate activity.
The present study deals with phytochemical on cinnamon and
thyme. The results from the GC of cinnamon oil showed that the
prevailing compound was cinnamaicaldehyde 55% and a lesser percentage
of other compounds including β-caryophylline 15%, trans-cinnamoayl
acetate10%, linalool 6.5% and eugenol 2.8%. While, The results from the
Summary
141
GC of thyme oil revealed the presence of the following compounds; the
major constituents of the thyme oil was thymol 45% followed by pcymene
37%, terpinol 7.5% and linalool 5%.
The present study revealed that, in Cinnamomum zeylanicum, the
total phenolic compounds and the flavonoids were 15 mg/g and 9.8 mg/g,
respectively. In Thymus vulgaris the total phenolic compounds and
flavonoids were 220 mg/g and 2 mg/g, respectively.
The pharmacopoeial parameters of cinnamon were as follows; the
water content was 8.7%, the ash content was 3.96%, the crude fiber was
22%, the protein content was 3% and the lipid content was 2%.
The pharmacopoeial parameters of thyme were as follows; the
water content was 7%, the ash content was 6.424%, the crude fiber was
16.10%, the protein content was 7.70% and the lipid content was 4.18%.