الفهرس 
Pediatric gastroesophageal reflux disease....Only 14 pages are availabe for public view
Abstract
SUMMARY
his interventional clinical trial was carried to evaluate the
difference between two proton pump inhibitor therapy
Omeprazole and Lansoprazole in patients who presented to the
Ain Shams Pediatric Gastroenterology Unit (ASPU), Children
Hospital, Ain Shams University presented with Gastroesophageal
reflux disease (GERD) in the Pediatric
Gastroenterology unit between Jan 2014 and Jan 2015.
This study was conducted on 60 patients presented with
GERD. Approval of the pediatric council was taken before
proceeding with this work. The study included 32 males and 28
females ranged between three months and nine months with mean
age 6.7±1.4 and 6.8±1.2 months.
The patients were randomly divided into two matched
groups; group A received omeprazole at dose of 1mg /kg/ day and
group B received Lansoprazole at the same dose.
All patients had medical history taking, with special
emphasis on gastrointestinal symptoms (vomiting, dysphagia,
hematemesis, abdominal pains, diarrhea, constipation, abdominal
distension and melena), associated extraintestinal symptoms
(chocking, cough, recurrent chest infection, allergy and weight
loss), family history of similar conditions and medication history.
T
Summary
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Careful clinical examination was done with special
emphasis on vital data (heart rate, respiratory rate, and
temperature), pallor, weight, skin allergy, abdominal examination
(distension, tenderness, rigidity and organomegaly) and
anthropometric measures; (weight for age and length for age in
terms of Z score value).
All patients had a laboratory assessment of hemoglobin %,
TLC, ALT, AST, Urea, Creatinin and RBS.
The present study revealed that vomiting was a constant
feature among all patients with GERD. Abdominal distension
among 95% of all patients, Diarrhea was reported by 6.7%.
Constipation was reported by 13.3% ofincluded patients of both
groups. and positive family history in 53.3% of all patients.
Regarding the extra intestinal manifestations the present
study revealed the presence of skin and nasal allergy in 50% of all
conducted patients, chocking among 33.3% of patient in both
groups, wheeze in 20% of all patients, nasal allergy among 20%
of all patients, skin rash among 11.7% of patients and recurrent
chest infection among 10% among patients of both groups. There
was no significant difference between both groups regarding
gastrointestinal manifestation and extra intestinal manifestation.Regarding hemoglobin% laboratory results showed that
there was no significant difference between both groups but
slightly higher mean in patients who received Omeprazole more
than patients who received Lansoprazole.
The results of the present study showed that the weight
gain in patients who received Lansoprazole was significantly
more than those who received Omeprazole.
The results of the present study showed that patients who
received Lansoprazole had significantly higher mean of age of
onset of vomiting and lower mean of duration of vomiting
compared to patients who received Omeprazole