Search In this Thesis
   Search In this Thesis  
العنوان
EFFECT OF PROLONGED USE OF CAFFEIINE
CIITRATE ON BONE DENSIITY /OF
PRETERM NEONATES.
المؤلف
Kamel ,Mona Saber Mohamed
هيئة الاعداد
باحث / منى صابر محمد كامل
مشرف / هشام عبد السميع عوض
مشرف / رانيا إبراهيم حسنى إسماعيل
الموضوع
PRETERM NEONATES-
تاريخ النشر
2015
عدد الصفحات
223P.;
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
طب الأطفال ، الفترة المحيطة بالولادة وصحة الطفل
تاريخ الإجازة
1/1/2015
مكان الإجازة
جامعة عين شمس - كلية الطب - طب الاطفال
الفهرس
Only 14 pages are availabe for public view

from 16

from 16

Abstract

Osteopenia of prematurity is a disease which affects preterm
infants due to early extra uterine life & many risk factors to
which preterm infants are exposed in the incubator such as,
delayed enteral feeding, prolonged immobilization, prolonged
periods of total parenteral nutrition with insufficient mineral
intake compared to the transplacental mineral supply from the
mother during intrauterine life.
Prevention of such disease is very important to avoid
bone fracture & childhood bone complications. Prevention could
be achieved by avoidance of risk factors & proper mineral
supply with proper calories.
The present study was designed to evaluate effect of
prolonged use of caffeine therapy on bone mineral density in
preterm neonates.
42 preterm infants, were enrolled in our study. They were
randomized into 2 groups; 20 preterm infants as a non-caffeine
group did not receive caffeine and 22 preterm infants as a
caffeine-group received caffeine therapy. Both groups received
the same dose of parenteral calcium by intermittent injection.
All neonates included in this study were subjected to:
Full history taking and complete clinical assessment
together with serum calcium, phosphorus, alkaline phosphatase,
sodium, potassium, creatinine, x-ray, abdominal ultrasound &
DEXA scan.
The results of the current study revealed that:
There was no statistical significant difference between
the two studied groups as regard body weight at the time of
discharge.
There was non statistical significant difference between
the two studied groups in the pretreatment levels of the serum Ca,
P, Mg, ALP, Cr, Na and K.
There was significant increase in serum ALP a day before
discharge in the caffeine group compared to non-caffeine group.
ALP significantly increased in patients who received
caffeine therapy > 14 compared to duration ≤ 14 days.
There was non statistical significant difference between
the two studied groups in the pretreatment levels of the serum Ca,
P, Mg, Cr, Na and K a day before discharge.
BMC significantly decreased in the caffeine compared to
non-caffeine group.
BMC significantly decreased in patients who received
caffeine therapy > 14 days compared to duration ≤ 14 days.
BMC highly significantly decreased in patients who
received caffeine therapy > 14 days compared to non-caffeine
group.There was non statistical significant difference in BMD in
the two studied groups.
There was non statistical significant difference in fracture
in the two studied groups and no one in the studied groups
developed nephrocalcinosis.
There was negative correlation between BMC and
alkaline phosphatase and a positive correlation between BMC
and the serum phosphorus level.
BMD has a negative correlation with alkaline
phosphatase and a positive correlation with the serum
phosphorus level after caffeine therapy.
There is negative correlation between duration of caffeine
therapy and BMC and a negative correlation between
cumulative dose of caffeine therapy and BMD.