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العنوان
Role of CT Enterography and MR Enterography in the Assessment of Small Bowel Crohn’s Disease\
المؤلف
Abd El Rasool, Rania Mohammed.
هيئة الاعداد
باحث / Rania Mohammed Abd El Rasool
مشرف / Sherine Kadry Amine
مشرف / Merhan Ahmed Nasr
مناقش / Merhan Ahmed Nasr
تاريخ النشر
2015.
عدد الصفحات
147p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
الفيزياء والفلك (المتنوعة)
تاريخ الإجازة
1/1/2015
مكان الإجازة
جامعة عين شمس - كلية العلوم - اشعة
الفهرس
Only 14 pages are availabe for public view

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Abstract

rohn’s disease is a multifactorial chronic inflammatory disease characterized by non caseating granuloma formation with a tendency toward remission and relapse, it affects any part of the GIT from mouth to anus with 80% small bowel involvement, most commonly the terminal ileum, with characteristic multiple discontinuous sites involvement (skip lesions) and transmural inflammation.
Crohn’s disease is common in North America, Northern Europe and Japan with a peak involvement in 2nd and 3rd decades of life (young patient population) with tendency to remission and relapse and complications as fibrosing strictures, sinus tracts, fistulas and abscesses formation.
Barium studies and endoscopy are the basic modalities in diagnosing Crohn’s disease in early stages with endoscopic guided biopsy and histopathological verification. Cross-sectional imaging (MDCT and MR enterography) with intraluminal and intravenous contrast material are with limited role in depicting subtle mucosal lesions but are most useful in assessment of symptomatic patients with known small bowel Crohn’s disease providing excellent visualization of most intestinal lesions and demonstrate their mural and extramural extent, also demonstrating complications such as sinus tracts, fistulas and abscesses.Also have great role in follow up and assessment of treatment.
In clinical settings, MDCT has been the cross sectional imaging modality of choice at most institutions due to its widespread availability, low cost and higher spatial and temporal resolutions relative to MR imaging, yet it is based on ionizing radiation.
However, because Crohn’s disease is commonly involving the young persons with a peak involvement between 15 and 25 years of age, with a tendency for remission and relapse that lead to high cumulative radiation doses imparted to the patients from multiple serial examinations needed to assess progression of the disease, detect and monitor response to treatment (high radiation burden). It is preferable to use a non ionizing radiation based modality such as MR imaging for diagnostic and follow up evaluation that help reduce patient’s lifetime radiation exposure .MRI provides superior soft tissue contrast and excellent depiction of fluid and edema, meanwhile has a high diagnostic sensitivity as that of the CT imaging and relatively higher safety profile of intravenous contrast material used in MR examination in relation to that used in CT examination.