الفهرس 
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Abstract
SUMMARY AND CONCLUSION
ttention has focused on exposure to environmental microbes and antigens. The ”hygiene hypothesis” considers the humans are more prone to allergic disorders because of a lifestyle that may be too ”clean”. In recent years, there has been a rise in the prevalence of asthma in developed countries, and is considered in its extent related to a change in our indigenous microbiota. H .pylori disappearance across the population represents a fundamental change in our human microbiota. Further, the disappearance of H pylori has preceded the rise in asthma prevalence. However, the relationship between childhood asthma and H .pylori infection is still questionable. So, this case control cross-sectional study aimed to assess frequency of H. pylori seropositivity in asthmatic children compared to healthy controls. The study was conducted on 180 children, 90 asthmatics with clinically defined asthma (GINA, 2008). who were recruited from Pediatric Chest Clinic, Children’s Hospital , Ain Shams University during the period from October 2013 to April 2014 and Ninety healthy non asthmatic non atopic controls, both asthmatics and controls were age and sex matched.
The age of the asthmatic group ranged between 1-17 with mean age 7.05±3.58, and for the healthy control group 2-
18 with mean age 7.51±4.19. Moreover, the current study found that asthmatic children were fifty two (57.80%) males and thirty eight (42.20%) female with a male to female ratio was 1.36:1. All studied patients were subjected to the following: Full medical history, through clinical examination and measurement of serum IgE for atopic status, serum IgG for H pylori infection was done. Analysis of the samples was done using ELISA technique. Collected data were reviewed, coded and entered PC where statistical analysis was done using SPSS (statistical package for social science) version 17. The study revealed that: H. pylori IgG seropostivity were found in 23/90 (25.6%) of asthmatic cases compared to 40/90 (44.4%) of controls with a highly significant difference (P-value 0.008). Also, there was a highly significant difference between the asthmatic group Median 19.6 ( IQR 15 – 57.8), and healthy control group Median 34 ( IQR 20.8 – 89.6) with (p- value 0.000) as regards H.pylori serum IgG titre.
Studying the relation between H.pylori IgG titre and asthma severity revealed a significant inverse relationship between H .pylori IgG titre and asthma severity.Increasing
asthma severity was assocaiated with a decrease in the IgG titre. Moreover, we found a significant positive correlation between H .pylori IgG titre in asthmatics and crowding index. H.pylori IgG titre was increasing with the increase in Crowding index. In conclusion, working on the relation between childhood asthma and H.pylori, it was found that childhood asthma was inversely related to exposure to Helicobacter pylori infection