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العنوان
Epidemiology and Risk Factors of Portal Vein Thrombosis in Egyptians \
المؤلف
Anwar, Mohammed El Sayed.
هيئة الاعداد
باحث / Mohammed El Sayed Anwar
مشرف / Mohammed Amin Sakr
مشرف / Hany Mansour Khalil Dabbous
مناقش / Mohammed Shaker Ghazy
تاريخ النشر
2014.
عدد الصفحات
147p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
أمراض الدم
تاريخ الإجازة
1/1/2014
مكان الإجازة
جامعة عين شمس - كلية الطب - طب المناطق الحارة
الفهرس
Only 14 pages are availabe for public view

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Abstract

Summary
The current study was designed to describe the epidemiology and risk factors of portal vein thrombosis and the clinical presentation of this disorder in a cohort of Egyptian patients who were referred to the Egyptian Association for the Study of Vascular Liver Disorders (EASVLD) affiliated to Tropical Medicine Department Ain Shams University (TMASU) {authorized by the Egyptian Medical Syndicate} or admitted to Ain Shams Centre for Organ Transplant (ASCOT).
To fulfill such purpose, we studied 70 patients with confirmed PVT. All patients were subjected to detailed history taking, clinical examination, radiological assessment with (duplex ultrasound, CT scan or MRI) and laboratory investigations including: liver profile tests, complete blood picture, kidney function tests and upper GIT endoscopy. Some patients were subjected to other laboratory investigations including: tumor markers, thrombophilia work up and bone marrow aspiration according to clinical suspicion and laboratory findings.
In the current study, males were 72.9% (n = 51). The mean age was 46.17+15.2 years. We found that the most
common symptom was abdominal enlargement (78.6%) and the
most common signs were splenomegaly and ascites (78.6%).
All patients had upper GIT endoscopy, 59 of them showed oesophageal varices (84.3%), 9 patients showed fundal varices (12.9%), 63 patients showed inflammatory gastric lesions and/ or PHG (90%) and 4 patients showed duodenal ulcers (5.7%).
The current study demonstrated that liver cirrhosis was the most common local risk factor for PVT (98.6%) followed by hepatocellular carcinoma (45.7%),While, the most common systemic risk factor was antithrombin III deficiency (69.6%) followed by protein C deficiency (66.7%) then MTHFR mutation (61.5%).