الفهرس | Only 14 pages are availabe for public view |
Abstract The life expectancy of patients with chronic kidney disease (CKD) is markedly reduced due to premature cardiovascular death. Endothelial dysfunction (ED) is closely linked to cardiovascular disease and outcome in patients with chronic kidney disease (CKD). Apelin is an adipocytokine that recently generated much interest; however, its role in CKD remains to be clarified. We found that VCAM-1 levels were significantly elevated in children with CKD as compared to controls. No difference in Apelin level between patients and controls was found. Apelin correlated positively with high density lipoprotein (HDL). VCAM-1 level positively correlated with triglycride, VCAM-1 levels were found to be significantly higher in patients who had weight and height below 3rd percentile and no correlation was found between apelin and VCAM-1. Also there was a significant correlation between VCAM-1 and measurement of inervetricular septum thickness (IVS), it also inversely correlated with Mg and vit B1 intake. Calcium intake strongly associated with apelin and LVESD was negatively associated with apelin. |