الفهرس 
CorrosivesOnly 14 pages are availabe for public view
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Abstract
• Background
Corrosives are a group of chemicals that have the capacity to cause tissue injury on contact by a chemical reaction. They most commonly affect the gastrointestinal tract (GIT), respiratory system and eyes (Naik, 2012).
Acids and alkalis are the two primary types of agents most often responsible for caustic exposures. Exposure to corrosive agents continues to be a leading toxicological source of injury for children and adults (Donovan et al., 2005).
The common caustic agents include strong acids and alkalis, concentrated weak acids and alkalis, oxidizers (with neutral pH) and alkylating agents (Donovan et al., 2005).
There are two types of corrosives effects, Alkali ingestion which causes liquefaction necrosis. This process includes protein dissolution, collagen destruction, cell membrane emulsification, sub mucosal vascular thrombosis and cell death. Acid ingestion causes coagulation necrosis. In this process, hydrogen (H+) ions desiccate epithelial cells producing an eschar. This process leads to edema, erythema, mucosal sloughing, ulceration and necrosis of tissues. Both acids and alkalis cause fibrosis (stricture formation) (Leikin et al., 2007). Known complications of corrosives are acute or delayed. Acute complications compromise airway, shock (due to hemorrhage, vomiting or third-space sequestration), gastrointestinal perforation, acute Pancreatitis, dysphagia, problems related to enteral feeding water supply and mediastinitis, or gastric leak/bleed leading to peritonitis (Lionte et al., 2007).
Delayed complications include stricture, obstruction, tracheoesophageal fistula and Carcinoma of esophagus (Haddad et al., 1998).
Management is based on the presenting clinical features on admission to the hospital.This can be divided intoemergency management, management of stable patient and long-term management (Naik, 2012).
• Aim of the Work
The aim of this work is to study and evaluate cases of corrosive intoxication admitted in the Poison Control Center of Ain Shams University Hospitals from 1/1/ 2013 till 31/12/2013 to determine the common agents, complications and the grading according to poisoning severity score.
• Patients and Methods
Patients
¬The Present study was conducted on cases of Corrosive Intoxication of all ages and both sexes admitted to Poison Control Center of Ain Shams University hospitals during the period from 1/1/2013 till 31/12/2013.
Methods
All Patients were subjected for the following:
Informed consent taken from patients, parents or guardian
Full History Taking
Clinical Examination
Investigations
Laboratory: All relevant lab investigations related to acute corrosive complications
Radiological: chest x-ray ,abdominal x-ray and other relevant imaging.
Follow up of patients: after the acute phase and after discharge by:
Barium swallow or Gastrografin swallow
Endoscopy when needed.
Management
Emergency and first aid measures, supportive treatment and surgical interference when needed.