الفهرس 
Introduction and aim of workOnly 14 pages are availabe for public view
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Abstract
Our study showed that:
•Chronic hepatitis c virus (HCV) is a major public health problem and a leading cause of chronic liver fibrosis.
•Evaluation of the degree of liver fibrosis is very important in the assessment of the liver disease condition.
•Liver biopsy was performed many years ago as a good invasive technique to evaluate the degree of liver fibrosis.
•Searching for another non-invasive technique for the evaluation of liver fibrosis is mandatory to be more convenient and more economic
•In the present retrospective study we analyzed the relationship between the histological grading of liver fibrosis and the GA/HbA1c ratio .
•There were no significant differences between the patients as regard age and sex.
•The mean values of GA/HbA1c ratio increased with the progression of the fibrosis stage, suggesting that the GA/HbA1c ratio was associated with the histological severity of liver fibrosis.
•Comparing F0-F3(no cirrhosis) and F4(cirrhosis) groups, we found a significant difference in several parameters which correlated with hepatic function. Between the two groups, the GA/HbA1c ratio was significantly higher in patients with cirrhosis.
•Comparing F0-F2(without severe fibrosis) and F3-F4(with severe fibrosis) groups, we found a significant difference in several parameters which correlated with hepatic function. Between the two groups, the GA/HbA1c ratio was significantly higher in patients with severe fibrosis.
•Comparing F0-F1(without significant fibrosis) and F2-F4(with significant fibrosis) groups, we found a significant difference in several parameters which correlated with hepatic function. Between the two groups, the GA/HbA1c ratio was significantly higher in patients with significant fibrosis.
•We evaluated the diagnostic performance of the increased GA/HbA1c ratio (>3.0) for the detection of patients with cirrhosis(F4),severe fibrosis(F3-F4) and significant fibrosis (F2-F4).
•When we combined GA/HbA1c and APRI to distinguish between F0-F1 patients and F2-F4 patients, the sensitivity and the specificity for the detection of liver fibrosis increased.