الفهرس 
Introduction and Aim of the WorkOnly 14 pages are availabe for public view
 |  | from | 118 |  |  |
| | | from | 118 | | |
Abstract
Summary
The female breast is intimately associated with a woman’s self-esteem, sexuality, and interpersonal relations. Breast reconstruction following mastectomy affects directly the quality of life of the patient by restoration of the self image and feeling complete again, and removal of the social stigma of having one or both breasts excised.
The goal of breast reconstruction is to recreate symmetric natural-appearing breasts while preserving patient safety and quality of life. Many techniques exist for breast reconstruction, but rarely do they produce true symmetry with the contralateral breast. The safety of the patient is essential and always should remain the primary concern in reconstructive procedures. These procedures should be tailored to the individual patient, taking into account the ultimate aesthetic outcome and the impact the reconstruction may have on the patient’s lifestyle.
The use of fat grafts has showed to be an effective method in breast reconstruction, giving very good asthetic results and with minimal donor site morbidities as compared to other autologous tissue reconstructive methods. However the use of fat graft only yielded the common complication encounterd by the patients, fat resorption and the decrease of breast volume. The use of ADCS has greatly overcome such obstacle. The application of stem cells has decreased the rate and amount of fat resorption, and consequently, the post-operative change of
volume. This will lead to less number of grafting sessions required to reach the desired volume. The use of BRAVA external tissue expander has additionally improved the results by increasing the vascularity of the recipient tissues, leading to much less resorption.
Human adipose tissue is a promising alternative source of stem cells. However, a greater understanding of the mechanisms of interactions among ADSCs, growth factors, and biomaterials on tissue regeneration is needed to advance the clinical utility of this therapy. Because chemokines derived from ADSCs may also affect cancer metastasis or invasion, additional findings are necessary to address the safety of ADSCs in the field of clinical tissue regeneration.