الفهرس 
Pre-EclampsiaOnly 14 pages are availabe for public view
 |  | from | 171 |  |  |
| | | from | 171 | | |
Abstract
Summary
Worldwide pre-eclampsia (PE) is the first cause of
maternal mortality, intrauterine growth retardation (IUGR), and
fetal prematurity (Crispi et al., 2008).
Pregnant women with preeclampsia or eclampsia
commonly have abnormal lipid metabolism combined with
oxidative stress, which can induce vascular endothelial cell
injury (Makenzie et al., 2012).
Uterine artery is the most studied vessel in the Doppler
evaluation in PE, because it represents the maternal vascular
condition, through the pulsatility and resistance index (PI and
RI respectively) and the presence of early diastolic notch
(Sehwarze et al., 2005).
This study was conducted at the Ain Shams University
Maternity Hospital in the period from October 2013 to April
2014.
The aim of this study was to determine whether high
plasma triglyceride levels and high uterine artery pulsatility
index are associated with pre-eclampsia or not.
In this study, age group ranged from 20 years to 35 years.
They were divided into two groups: patients group (preeclamptic
group) consisted of 66 patients with age ranged from
20 years to 35 years and with mean ± SD 27.39 ± 4.30 years,
and control group consisted of 66 patients with age ranged from
20 years to 34 years and with mean ± SD 26.5 3 ± 4.18 years.
All patients were of the same socioeconomic status. There were
no abnormal findings in the personal history, and menstrual
history. Special interest was directed towards past history of
systemic diseases such as diabetes mellitus, renal disease,
autoimmune disease, and drug history that alter lipid
metabolisim e.g steroids.
Uterine artery pulsatility index (PI) and serum level of
triglyceride (TG) were measured to all participants in the third
trimesters.
In normal pregnancy group, PI ranged 0.61-0.85 with
mean value 0.74±0.08 and pre-eclampsia group ranged 0.75-
2.39 with mean value 1.37±0.48. There was statistical
significant difference between the two studied groups regarding
PI (P< 0.05). The RR (relative risk) was 2.85 indicating that the
association between preeclampsia and high uterine artery PI is
2.85 times more than normal.
In normal pregnancy group, TG ranged 120-185 with
mean value 154.67±20.82 and pre-eclampsia group ranged 123-
252 with mean value 189.41±39.34. There was statistical
significant difference between the two studied groups regarding
T.G (P< 0.05). The RR (relative risk) was 2.33 indicating that
the association between preeclampsia and hypertriglyceridemia
is 2.33 times more than normal.
In normal pregnancy group, proteinuria 1+, proteinuria 2+,
and proteinuria 3+ were the same 0 (0.00%) while in preeclampsia
group were 36 (54.5%), 30 (44.5%) and 0 (0.0%)
respectively. There was statistical significant difference
between the two studied groups regarding proteinuria (P <
0.05).
In normal pregnancy group, systolic BLP ranged 100-130
with mean value 115.45±8.50 and in pre-eclampsia group
ranged 140-160 with mean value 147.12±5.95. There was
statistical significant difference between the two studied groups
regarding systolic BLP (P< 0.05).
In normal pregnancy group, diastolic BLP ranged 70-85
with mean value 75.98±6.35 and pre-eclampsia group ranged
90-105 with mean value 95.08±5.00. There was statistical
significant difference between the two studied groups regarding
diastolic BLP (P < 0.05).
It was found that in pre-eclamptic group PI had a positive
correlation with systolic BLP while it had not a positive
correlation with the other parameters.