الفهرس 
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Abstract
The present investigation was carried out on 512 animals with a clinical picture o~ lumpy skin disease during 1988 at El Suez, El Tal El Kebeer and El NoOa~ia. All ages groups, both sexes and breeds o~ cattle are suscea tible to lumpy skin disease. - The morbidity rate ranged ~rom 8.8% to 46.6 % and the mortality rate was ~rom 0 - 2%.The clinical ~indings were pyrexia (4loC) which lasted 9 -21 days, inappetance, salivatlon, lacrimation and nasal dicharge, accompanled by generalized eruption o~ intradermal skin nodules scattered all over the skin. Occasionally the nodules ~ound on mucous membrane o~ the eyes. The nooules varied in numbers and its Size was ranged ~rom 0.5 to 5 cm in diameter. Some animals showed Edema o~ the limbs and ventral aspect o~ the abdomen as well as swelling o~ the prescapular ana pre~emoral lymph glands. Post-mortem examination o~ two dead animals revealed skin nodules (0.5 5 cm) in Olameter lnvolvlng all layers o~ the skin. With or with out ~morrnagic spots below then. Congestion To the upper respira~IY tract wlth emphyzematous areas on the lungs. The g~strO-int~inal tract. the spleen. lymph nooes, liver and the kldney ~ also congested. Swelling and congestion To the &UperTicial~Ph glands were observed. Histopathologlcal Tindings revealed the presence o~ lntrac ytoplasmic inclusion bodies in epithelial cells o~ the skin nodules, degenerative changes in the epidermis and oedematous in Tilteration in epithelial connectlve tissue. Haematological studies revelaed that the total erythrocytlc count and PCV showed a signi~lcant DROP in Olseaseo animals than apparently healthy ones. While the haemoglobln content and total leucocytic count showed no signi~lcant diTTerence between both the diseased and apparently healthy animals. Serum biochemical analysis showed increased in serum glutamlc oxaloacetic and glutamlc pyruvIc transanimases while serum alkaline phosphatase reported a signiTicant decreased activity. Serum electrophoretogram o~ dlseased cows recorded marked alteration in its Tractions and subTractIons, the albumen and beta-globuline percenta~ are SlgnlTicantly dropped while alpha and gamma-globulIn perc”tages are signiTicantly elevated. Egg InoculatIon o~ davs emoryonated eggs WIth the suspension aT skin nodules S~d tne presence at pock leSIons on (CAM) • aTter 5th - 7th passageil’ The viral antig icn oetalnee Tram CAM was identiTied by CFT give positIve res~l 1:8 dilutIon. ..The.-.an~ibod~e.isn diseased cattle as traced by using to diTTerent serological method namely serum neutralizat.on test and complement Tixat.on test. The neutralizing antibody as cemonstrated in 24 out oT 64 serum samoles (37.5%) at 1:4 dilut.on ••n.le the comolement Tix.ng antiboCv was cetected in 51 out oT 64 serum samples (79.6%) at 1/4 to 1/16.