الفهرس 
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Abstract
Zingiber officinale Roscoe (Zingiberaceae) has been cultivated for thousands of years both as a spice and for medicinal purposes. In herbal medicine, it is used as a circulatory stimulant, a cold and flu treatment and for digestive disorders. In the present study, ginger rhizomes successive extracts (petroleum ether, chloroform and ethanol) were phytochemical screened and examined against liver fibrosis induced by carbon tetrachloride in rats. Animals were divided into nine groups. Group: 1 served as control, groups 2-4 orally received each extract with a dose 200mg/kg body weight two times/ week for six consecutive weeks. Group 5 intraperitoneally injected with CCl4 (0.5 ml/kg body weight) for the same duration. Groups 6-9 forced at the same time with CCl4 and extracts or silymarin (100mg/kg body weight|). The evaluation was done through measuring antioxidant parameters; glutathione (GSH), superoxide dismutase (SOD) and malondialdehyde (MDA). The work was extended to measure liver marker enzymes; succinate dehydrogenase (SDH), lactate dehydrogenase (LDH), glucose-6- phosphatase (G-6-Pase), acid phosphatase (AP) and 5`- nucleotidase (5`NT). Liver function enzymes; aspartate and alanine aminotransferases (AST and ALT), alkaline phosphatase (ALP¬) and gamma glutamyl transferase (GGT) were estimated. Liver histopathological analysis and collagen content were also evaluated. Treatment with different extracts improved all parameters by variable degrees. In conclusion, ethanol extract showed the most potent effect than chloroform, while petroleum ether recorded the lowest improvement level. Further studies are needed for its clinical application.